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Molecules 2016, 21(8), 1075; doi:10.3390/molecules21081075

Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides

Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin 150040, China
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Academic Editors: Nancy D. Turner and Isabel C. F. R. Ferreira
Received: 19 May 2016 / Revised: 28 July 2016 / Accepted: 1 August 2016 / Published: 17 August 2016
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Four new steroid saponins 14 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values of 43.90 and 57.90 μM, respectively. View Full-Text
Keywords: Asparagaceae; furostanol saponin; spirostanol saponin; MTT; cytotoxicity Asparagaceae; furostanol saponin; spirostanol saponin; MTT; cytotoxicity
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Yang, B.-Y.; Zhang, J.; Liu, Y.; Kuang, H.-X. Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides. Molecules 2016, 21, 1075.

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