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Molecules 2016, 21(8), 1046; doi:10.3390/molecules21081046

Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents

1
Department of Organic Chemistry and Technology, Budapest University of Technology and Economics, 1521 Budapest, Hungary
2
Gedeon Richter Plc., 1475 Budapest, Hungary
*
Author to whom correspondence should be addressed.
Academic Editor: Roman Dembinski
Received: 15 July 2016 / Revised: 2 August 2016 / Accepted: 3 August 2016 / Published: 11 August 2016
(This article belongs to the Special Issue Recent Advances in Organophosphorus Chemistry)
View Full-Text   |   Download PDF [3436 KB, uploaded 11 August 2016]   |  

Abstract

The syntheses of hydroxymethylenebisphosphonic acid derivatives (dronic acid derivatives) starting from the corresponding substituted acetic acids and P-reagents, mainly phosphorus trichloride and phosphorous acid are surveyed according to the solvents applied. The nature of the solvent is a critical point due to the heterogeneity of the reaction mixtures. This review sheds light on the optimum choice and ratio of the P-reactants, and on the optimum conditions. View Full-Text
Keywords: hydroxymethylenebisphosphonic acid (dronic acid) derivatives; solvent; P-reagents; synthesis hydroxymethylenebisphosphonic acid (dronic acid) derivatives; solvent; P-reagents; synthesis
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MDPI and ACS Style

Nagy, D.I.; Grün, A.; Garadnay, S.; Greiner, I.; Keglevich, G. Synthesis of Hydroxymethylenebisphosphonic Acid Derivatives in Different Solvents. Molecules 2016, 21, 1046.

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