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Molecules 2016, 21(8), 1056; doi:10.3390/molecules21081056

Determination of the Absolute Configurations of Chiral Drugs Using Chiroptical Spectroscopy

Department of Chemistry, Vanderbilt University, Nashville, TN 37235, USA
Academic Editor: Claudio Villani
Received: 12 July 2016 / Revised: 2 August 2016 / Accepted: 4 August 2016 / Published: 12 August 2016
(This article belongs to the Special Issue Chiral Drugs)
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Abstract

Chiroptical spectroscopy has emerged as a promising tool for the determination of absolute configurations and predominant conformations of chiral molecules in academic laboratories. This promise has led to the adaption of chiroptical spectroscopic methods as valuable tools in chiral drug discovery research programs of the pharmaceutical industry. Most major pharmaceutical companies have invested in in-house chiroptical spectroscopy applications and reported successful outcomes. In the context of continuously increasing applications of chiroptical spectroscopy for chiral molecular structure determination, a review of recent developments and applications for chiral drugs is presented in this manuscript. View Full-Text
Keywords: chiral; spectroscopy; drugs; electronic circular dichroism; optical rotation; vibrational circular dichroism; vibrational Raman optical activity; absolute configuration; conformation chiral; spectroscopy; drugs; electronic circular dichroism; optical rotation; vibrational circular dichroism; vibrational Raman optical activity; absolute configuration; conformation
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Polavarapu, P.L. Determination of the Absolute Configurations of Chiral Drugs Using Chiroptical Spectroscopy. Molecules 2016, 21, 1056.

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