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Molecules 2016, 21(8), 1026; doi:10.3390/molecules21081026

Anti-Diabetic Activity and Metabolic Changes Induced by Andrographis paniculata Plant Extract in Obese Diabetic Rats

1
Laboratory of Natural Products, Institute of Bioscience, University Putra Malaysia, Serdang 43400, Malaysia
2
Faculty of Medicine and Health Sciences, University Putra Malaysia, Serdang 43400, Malaysia
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editors: Nancy D. Turner and Isabel C. F. R. Ferreira
Received: 23 June 2016 / Revised: 20 July 2016 / Accepted: 28 July 2016 / Published: 9 August 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [3744 KB, uploaded 9 August 2016]   |  

Abstract

Andrographis paniculata is an annual herb and widely cultivated in Southeast Asian countries for its medicinal use. In recent investigations, A. paniculata was found to be effective against Type 1 diabetes mellitus (Type 1 DM). Here, we used a non-genetic out-bred Sprague-Dawley rat model to test the antidiabetic activity of A. paniculata against Type 2 diabetes mellitus (Type 2 DM). Proton Nuclear Magnetic Resonance (1H-NMR) spectroscopy in combination with multivariate data analyses was used to evaluate the A. paniculata and metformin induced metabolic effects on the obese and obese–diabetic (obdb) rat models. Compared to the normal rats, high levels of creatinine, lactate, and allantoin were found in the urine of obese rats, whereas, obese-diabetic rats were marked by high glucose, choline and taurine levels, and low lactate, formate, creatinine, citrate, 2-oxoglutarate, succinate, dimethylamine, acetoacetate, acetate, allantoin and hippurate levels. Treatment of A. paniculata leaf water extract was found to be quite effective in restoring the disturbed metabolic profile of obdb rats back towards normal conditions. Thisstudy shows the anti-diabetic potential of A. paniculata plant extract and strengthens the idea of using this plant against the diabetes. Further classical genetic methods and state of the art molecular techniques could provide insights into the molecular mechanisms involved in the pathogenesis of diabetes mellitus and anti-diabetic effects of A. paniculata water extract. View Full-Text
Keywords: Andrographis paniculata; metabolomics; diabetes; obese-diabetic rat; type 2 DM; NMR Andrographis paniculata; metabolomics; diabetes; obese-diabetic rat; type 2 DM; NMR
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Akhtar, M.T.; Bin Mohd Sarib, M.S.; Ismail, I.S.; Abas, F.; Ismail, A.; Lajis, N.H.; Shaari, K. Anti-Diabetic Activity and Metabolic Changes Induced by Andrographis paniculata Plant Extract in Obese Diabetic Rats. Molecules 2016, 21, 1026.

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