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Molecules 2016, 21(7), 962; doi:10.3390/molecules21070962

Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata

1
Guangdong Provincial Key Laboratory of Bio-Control for Forest Diseases and Pests, Guangdong Academy of Forestry, Guangzhou 510520, China
2
Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
3
Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China
4
College of Life Sciences, University of Chinese Academy of Sciences, Beijing 100049, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhees
Received: 28 June 2016 / Revised: 18 July 2016 / Accepted: 19 July 2016 / Published: 22 July 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [806 KB, uploaded 25 July 2016]   |  

Abstract

Two new pentacyclic triterpene saponins, named akebiaoside K (1) and akebiaoside N (2), were isolated from the leaves of Akebia trifoliata, together with five known triterpenoids 37. They were all isolated from the leaves of A. trifoliata for the first time. Their structures were established by spectral and chemical means. Triterpenes 5 and 7 were found to show moderate in vitro cytotoxicity against human tumor A549, HeLa and HepG2 cell lines, with IC50 values ranging from 0.023 to 0.038 mM. Triterpenes 57 were further revealed to show significant in vitro α-glucosidase inhibitory activity with IC50 values from 0.040 to 0.220 mM, making them more potent than the reference compound acarbose (IC50 0.409 mM). Meanwhile, no obvious inhibitory effects were observed for the isolated triterpene saponins 14 in both bioactivity assays. View Full-Text
Keywords: Akebia trifoliata; triterpene saponins; α-glucosidase inhibitor; cytotoxicity Akebia trifoliata; triterpene saponins; α-glucosidase inhibitor; cytotoxicity
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MDPI and ACS Style

Xu, Q.-L.; Wang, J.; Dong, L.-M.; Zhang, Q.; Luo, B.; Jia, Y.-X.; Wang, H.-F.; Tan, J.-W. Two New Pentacyclic Triterpene Saponins from the Leaves of Akebia trifoliata. Molecules 2016, 21, 962.

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