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Molecules 2016, 21(7), 965; doi:10.3390/molecules21070965

Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer

Faculty of Health Sciences, University of Macau, Avenida da Universidade, Taipa, Macau SAR 999078, China
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Academic Editor: Helena Vasconcelos
Received: 10 June 2016 / Revised: 16 July 2016 / Accepted: 19 July 2016 / Published: 22 July 2016
(This article belongs to the Special Issue New Approaches to Counteract Drug Resistance in Cancer)
View Full-Text   |   Download PDF [648 KB, uploaded 22 July 2016]   |  

Abstract

Epithelial–mesenchymal transition (EMT) is known to play an important role in cancer progression, metastasis and drug resistance. Although there are controversies surrounding the causal relationship between EMT and cancer metastasis, the role of EMT in cancer drug resistance has been increasingly recognized. Numerous EMT-related signaling pathways are involved in drug resistance in cancer cells. Cells undergoing EMT show a feature similar to cancer stem cells (CSCs), such as an increase in drug efflux pumps and anti-apoptotic effects. Therefore, targeting EMT has been considered a novel opportunity to overcome cancer drug resistance. This review describes the mechanism by which EMT contributes to drug resistance in cancer cells and summarizes new advances in research in EMT-associated drug resistance. View Full-Text
Keywords: epithelial–mesenchymal transition; drug resistance; chemotherapy; cancer stem cells epithelial–mesenchymal transition; drug resistance; chemotherapy; cancer stem cells
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Du, B.; Shim, J.S. Targeting Epithelial–Mesenchymal Transition (EMT) to Overcome Drug Resistance in Cancer. Molecules 2016, 21, 965.

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