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Molecules 2016, 21(7), 898; doi:10.3390/molecules21070898

Protective Effects of Costunolide against Hydrogen Peroxide-Induced Injury in PC12 Cells

1
Department of Intensive Care Medicine, Chi Mei Medical Center, Liouying, Tainan City 73657, Taiwan
2
Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung City 83102, Taiwan
3
Bio-Medical Technology Developmental Center, Fooyin University, Kaohsiung City 83102, Taiwan
4
Department of Medical Technology, School of Medical and Health Sciences, Fooyin University, Kaohsiung City 83102, Taiwan
5
Department of Medical Research, Fooyin University Hospital, Ping-Tung County 92847, Taiwan
6
Department of Mackay Memorial Hospital Taitung Branch, Taitung County 95054, Taiwan
7
Department of Medical Research, Chiayi Christian Hospital, Chiayi City 60002, Taiwan
8
Cancer Center, Kaohsiung Medical University Hospital, Kaohsiung City 80708, Taiwan
9
Department of Nursing, Min-Hwei Junior College of Health Care Management, Tainan City 73658, Taiwan
These authors contributed equally to this work.
*
Authors to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 9 April 2016 / Revised: 4 July 2016 / Accepted: 5 July 2016 / Published: 9 July 2016
View Full-Text   |   Download PDF [1991 KB, uploaded 9 July 2016]   |  

Abstract

Oxidative stress-mediated cellular injury has been considered as a major cause of neurodegenerative diseases including Alzheimer’s and Parkinson’s diseases. The scavenging of reactive oxygen species (ROS) mediated by antioxidants may be a potential strategy for retarding the diseases’ progression. Costunolide (CS) is a well-known sesquiterpene lactone, used as a popular herbal remedy, which possesses anti-inflammatory and antioxidant activity. This study aimed to investigate the protective role of CS against the cytotoxicity induced by hydrogen peroxide (H2O2) and to elucidate potential protective mechanisms in PC12 cells. The results showed that the treatment of PC12 cells with CS prior to H2O2 exposure effectively increased the cell viability. Furthermore, it decreased the intracellular ROS, stabilized the mitochondria membrane potential (MMP), and reduced apoptosis-related protein such as caspase 3. In addition, CS treatment attenuated the cell injury by H2O2 through the inhibition of phosphorylation of p38 and the extracellular signal-regulated kinase (ERK). These results demonstrated that CS is promising as a potential therapeutic candidate for neurodegenerative diseases resulting from oxidative damage and further research on this topic should be encouraged. View Full-Text
Keywords: reactive oxygen species; costunolide; PC12 cells; mitochondria membrane potential reactive oxygen species; costunolide; PC12 cells; mitochondria membrane potential
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MDPI and ACS Style

Cheong, C.-U.; Yeh, C.-S.; Hsieh, Y.-W.; Lee, Y.-R.; Lin, M.-Y.; Chen, C.-Y.; Lee, C.-H. Protective Effects of Costunolide against Hydrogen Peroxide-Induced Injury in PC12 Cells. Molecules 2016, 21, 898.

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