Next Article in Journal
Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications
Next Article in Special Issue
Decrystallization of Crystals Using Gold “Nano-Bullets” and the Metal-Assisted and Microwave-Accelerated Decrystallization Technique
Previous Article in Journal
Synthesis and Cytotoxic Activity of Biphenylurea Derivatives Containing Indolin-2-one Moieties
Article Menu
Issue 6 (June) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(6), 763; doi:10.3390/molecules21060763

Bioaccumulation and Subchronic Toxicity of 14 nm Gold Nanoparticles in Rats

1
DST/NWU Preclinical Drug Development Platform, Faculty of Health Sciences, North-West University, Potchefstroom 2531, South Africa
2
Necsa, South African Nuclear Energy Corporation (SOC) Ltd., Pelindaba 2025, South Africa
Present Address: Division of Pharmaceutics, Faculty of Pharmacy, Rhodes University, Grahamstown 6139, South Africa
*
Author to whom correspondence should be addressed.
Academic Editor: Kadir Aslan
Received: 12 May 2016 / Revised: 2 June 2016 / Accepted: 6 June 2016 / Published: 10 June 2016
(This article belongs to the Special Issue Gold Nanoparticles for Biomedical Applications)
View Full-Text   |   Download PDF [4104 KB, uploaded 10 June 2016]   |  

Abstract

Colloidal suspensions of 14 nm gold nanoparticles (AuNPs) were repeatedly administered intravenously at three dose levels (0.9, 9 and 90 µg) to male Sprague Dawley rats weekly for 7 weeks, followed by a 14-day washout period. After sacrificing, the amount of gold was quantified in the liver, lungs, spleen, skeleton and carcass using neutron activation analysis (NAA). During the study, pre- and post (24 h) administration blood samples were collected from both the test and control groups, the latter which received an equal injection volume of normal saline. General health indicators were monitored together with markers of kidney and liver damage for acute and subchronic toxicity assessment. Histopathological assessments were done on the heart, kidneys, liver, lungs and spleen to assess any morphological changes as a result of the exposure to AuNPs. The mass measurements of all the groups showed a steady increase with no signs of overt toxicity. The liver had the highest amount of gold (µg) per gram of tissue after 56 days followed by the spleen, lungs, skeleton and carcass. Markers of kidney and liver damage showed similar trends between the pre and post samples within each group and across groups. The histopathological examination also showed no hepatotoxicity and nephrotoxicity. There was accumulation of Au in tissues after repeated dosing, albeit with no observable overt toxicity, kidney or liver damage. View Full-Text
Keywords: gold nanoparticles; bioaccumulation; liver and kidney damage; Sprague Dawley rats gold nanoparticles; bioaccumulation; liver and kidney damage; Sprague Dawley rats
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Rambanapasi, C.; Zeevaart, J.R.; Buntting, H.; Bester, C.; Kotze, D.; Hayeshi, R.; Grobler, A. Bioaccumulation and Subchronic Toxicity of 14 nm Gold Nanoparticles in Rats. Molecules 2016, 21, 763.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top