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Molecules 2016, 21(6), 761; doi:10.3390/molecules21060761

Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications

1
Department of Inorganic Chemistry, Physical Chemistry and Electrochemistry, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Polizu Street, 011061 Bucharest, Romania
2
Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, University Politehnica of Bucharest, 1–7 Polizu Street, 011061 Bucharest, Romania
3
Microbiology Immunology Department, Faculty of Biology, University of Bucharest, 1–3 Portocalelor Lane, Sector 5, 77206 Bucharest, Romania
4
Research Institute of the University of Bucharest, Life, Environmental and Earth Sciences, Spl. Independentei 91–95, 0500088 Bucharest, Romania
5
Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, PetruRares Street, No. 2, 200349 Craiova, Romania
6
Research Center for Clinical and Experimental Medicine, University of Medicine and Pharmacy of Craiova 2 PetruRareş Street, 200349 Craiova, Romania
7
Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, PetruRares Street, No. 2, 200349 Craiova, Romania
8
Department of Life and Environmental Physics, “HoriaHulubei” National Institute of Physics and Nuclear Engineering, Magurele, 077125 Bucharest, Romania
9
Lasers Department, National Institute for Laser, Plasma and Radiation Physics, Magurele, 077125 Bucharest, Romania
10
Laboratory of Microbiology, Biotechnology and Hygiene, Department of Food Science and Technology, Faculty of Agricultural Development, Democritus University of Thrace, 68200 Orestiada, Greece
*
Author to whom correspondence should be addressed.
Academic Editor: Didier Astruc
Received: 7 March 2016 / Revised: 3 June 2016 / Accepted: 6 June 2016 / Published: 10 June 2016
(This article belongs to the Special Issue Pharmaceutical Nanotechnology: Novel Approaches)
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Abstract

The aim of our research activity was to obtain a biocompatible nanostructured composite based on naturally derived biopolymers (chitin and sodium alginate) loaded with commercial antibiotics (either Cefuroxime or Cefepime) with dual functions, namely promoting wound healing and assuring the local delivery of the loaded antibiotic. Compositional, structural, and morphological evaluations were performed by using the thermogravimetric analysis (TGA), scanning electron microscopy (SEM), and fourier transform infrared spectroscopy (FTIR) analytical techniques. In order to quantitatively and qualitatively evaluate the biocompatibility of the obtained composites, we performed the tetrazolium-salt (MTT) and agar diffusion in vitro assays on the L929 cell line. The evaluation of antimicrobial potential was evaluated by the viable cell count assay on strains belonging to two clinically relevant bacterial species (i.e., Escherichia coli and Staphylococcus aureus). View Full-Text
Keywords: chitin; sodium alginate; drug delivery; cefepime; cefuroxime; L929 cell line; rats; anti-biofilm chitin; sodium alginate; drug delivery; cefepime; cefuroxime; L929 cell line; rats; anti-biofilm
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Rădulescu, M.; Holban, A.M.; Mogoantă, L.; Bălşeanu, T.-A.; Mogoșanu, G.D.; Savu, D.; Popescu, R.C.; Fufă, O.; Grumezescu, A.M.; Bezirtzoglou, E.; Lazar, V.; Chifiriuc, M.C. Fabrication, Characterization, and Evaluation of Bionanocomposites Based on Natural Polymers and Antibiotics for Wound Healing Applications. Molecules 2016, 21, 761.

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