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Molecules 2016, 21(6), 719; doi:10.3390/molecules21060719

Hydrogen Bonding: Between Strengthening the Crystal Packing and Improving Solubility of Three Haloperidol Derivatives

1
Department of Pharmaceutical Sciences, Southwestern Oklahoma State University, 100 Campus Drive, Weatherford, OK 73096-3098, USA
2
Department of Pharmaceutical Sciences, MCPHS-University-Boston, 179 Longwood Ave, Boston, MA 02115, USA
3
WuXi AppTec, Cambridge, MA 02142, USA
4
College of Pharmacy, California Northstate University, 9700 W Taron Drive, Elk Grove, CA 95757, USA
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Sohrab Rohani
Received: 16 January 2016 / Revised: 9 May 2016 / Accepted: 21 May 2016 / Published: 1 June 2016
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [3216 KB, uploaded 1 June 2016]   |  

Abstract

The purpose of this study is to confirm the impact of polar functional groups on inter and intra-molecular hydrogen bonding in haloperidol (HP) and droperidol (DP) and, hence, their effects on dissolution using a new approach. To confirm our theory, a new molecule: deshydroxy-haloperidol (DHP) was designed and its synthesis was requested from a contract laboratory. The molecule was then studied and compared to DP and HP. Unlike DHP, both the HP and DP molecules have hydrogen donor groups, therefore, DHP was used to confirm the relative effects of the hydrogen donor group on solubility and crystal packing. The solid dispersions of the three structurally related molecules: HP, DP, and DHP were prepared using PVPK30, and characterized using XRPD and IR. A comparative dissolution study was carried out in aqueous medium. The absence of a hydrogen bonding donor group in DHP resulted in an unexpected increase in its aqueous solubility and dissolution rate from solid dispersion, which is attributed to weaker crystal pack. The increased dissolution rate of HP and DP from solid dispersions is attributed to drug-polymer hydrogen bonding that interferes with the drug-drug intermolecular hydrogen bonding and provides thermodynamic stability of the dispersed drug molecules. The drug-drug intermolecular hydrogen bond is the driving force for precipitation and crystal packing. View Full-Text
Keywords: drug crystal packing; hydrogen bonding; solid dispersion; haloperidol-related compounds; molecular interaction; hydrophobic interaction; droperidol; deshydroxyhaloperidol drug crystal packing; hydrogen bonding; solid dispersion; haloperidol-related compounds; molecular interaction; hydrophobic interaction; droperidol; deshydroxyhaloperidol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Saluja, H.; Mehanna, A.; Panicucci, R.; Atef, E. Hydrogen Bonding: Between Strengthening the Crystal Packing and Improving Solubility of Three Haloperidol Derivatives. Molecules 2016, 21, 719.

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