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Molecules 2016, 21(3), 391; doi:10.3390/molecules21030391

Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors

1
Department of Chemistry, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
2
Division of Genetics and Molecular Biology, Institute of Biological Sciences, Faculty of Science, University of Malaya, Kuala Lumpur 50603, Malaysia
3
Institut de Chimie des Substances Naturelles, Centre National de la Recherche Scientifique, 91198 Gif-sur-Yvette, Cedex, France
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 26 January 2016 / Revised: 10 March 2016 / Accepted: 15 March 2016 / Published: 21 March 2016
(This article belongs to the Section Natural Products)
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Abstract

Malabaricones A–C (1–3) and giganteone A (4) were isolated from the bark of Myristica cinnamomea King. Their structures were elucidated and characterized by means of NMR and MS spectral analyses. These isolates were evaluated for their anti-quorum sensing activity using quorum sensing biosensors, namely Escherichia coli [pSB401] and Escherichia coli [pSB1075], whereby the potential of giganteone A (4) as a suitable anti-quorum sensing agent was demonstrated. View Full-Text
Keywords: Myristica cinnamomea King; Myristicaceae; acylphenols; dimeric acylphenols; anti-quorum sensing activity Myristica cinnamomea King; Myristicaceae; acylphenols; dimeric acylphenols; anti-quorum sensing activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Sivasothy, Y.; Krishnan, T.; Chan, K.-G.; Abdul Wahab, S.M.; Othman, M.A.; Litaudon, M.; Awang, K. Quorum Sensing Inhibitory Activity of Giganteone A from Myristica cinnamomea King against Escherichia coli Biosensors. Molecules 2016, 21, 391.

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