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Molecules 2016, 21(3), 336; doi:10.3390/molecules21030336

New Anti-HBV C-Boivinopyranosyl Flavones from Alternanthera philoxeroides

1
Department of Pharmaceutical Chemistry, Beijing Institute of Radiation Medicine, Beijing 100850, China
2
Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Nancy D. Turner
Received: 19 January 2016 / Revised: 14 February 2016 / Accepted: 4 March 2016 / Published: 14 March 2016
(This article belongs to the Collection Bioactive Compounds)
View Full-Text   |   Download PDF [763 KB, uploaded 14 March 2016]   |  

Abstract

C-boivinopyranosyl flavones have rarely been isolated from nature. In the search for anti-HBV (hepatitis b virus) constituents of Alternanthera philoxeroides, two new compounds, luteolin-6-C-β-d-boivinopyranosyl-3′-O-β-d-glucopyranoside (1) and chrysoeriol-6-C-β-d-boivinopyranosyl-4′-O-β-d-glucopyranoside (2), along with three known C-boivinopyranosyl flavones (compounds 3–5) were isolated. Their structures were determined by spectroscopic analyses including 1D and 2D NMR, HR-ESI-MS, IR spectra. Compounds 1, 2 and 3 showed significant anti-HBV activities through specifically inhibiting the secretion of HBsAg in HepG2.2.15. View Full-Text
Keywords: C-boivinopyranosyl flavones; Alternanthera philoxeroides; anti-HBV activity C-boivinopyranosyl flavones; Alternanthera philoxeroides; anti-HBV activity
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Li, B.; Guo, Q.-L.; Tian, Y.; Liu, S.-J.; Wang, Q.; Chen, L.; Dong, J.-X. New Anti-HBV C-Boivinopyranosyl Flavones from Alternanthera philoxeroides. Molecules 2016, 21, 336.

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