NMR Study on the Inclusion Complexes of β-Cyclodextrin with Isoflavones
AbstractThe structure of the inclusion complexes of β-cyclodextrin (β-CD) with daidzein and daidzin in D2O were investigated using NMR spectroscopy. For the β-CD and daidzein system, two types of 1:1 complexes were formed with the daidzein deeply inserted into the CD cavity with different orientations. For the β-CD/daidzin system, a 1:1 complex was formed with the flavonoid part of daidzin entering the CD cavity from the wide rim. The inclusion complexes determined by NMR were constructed using molecular docking. Furthermore, the mixture of puerarin, daidzein and daidzin, which are the major isoflavonoid components present in Radix puerariae, was analyzed by diffusion-ordered spectroscopy (DOSY) alone and upon addition of β-CD in order to mimic chromatographic conditions and compare their binding affinities. View Full-Text
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Zhao, R.; Sandström, C.; Zhang, H.; Tan, T. NMR Study on the Inclusion Complexes of β-Cyclodextrin with Isoflavones. Molecules 2016, 21, 372.
Zhao R, Sandström C, Zhang H, Tan T. NMR Study on the Inclusion Complexes of β-Cyclodextrin with Isoflavones. Molecules. 2016; 21(4):372.Chicago/Turabian Style
Zhao, Rui; Sandström, Corine; Zhang, Haiyang; Tan, Tianwei. 2016. "NMR Study on the Inclusion Complexes of β-Cyclodextrin with Isoflavones." Molecules 21, no. 4: 372.
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