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Molecules 2016, 21(2), 209; doi:10.3390/molecules21020209

Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil

1
Laboratório de Microbiologia e Biologia Molecular, Universidade Regional do Cariri, Crato-CE, CEP 63105-000, Brazil
2
Post-Graduate Program in Biological Sciences, Biochemical Toxicology, Federal University of Santa Maria, Santa Maria-RS, CEP 97105-900, Brazil
3
Program of Post-Graduation in Molecular Bioprospection, Laboratory of Pharmacology and Molecular Chemistry, Chemistry Biology Department, Regional University of Cariri, Crato, CEP 63105-000, Brazil
4
Departamenro de Bioquímica, Instituto de Ciências Básica da Saúde, Universidade Federal do Rio Grande do Sul, Porto Alegre-RS, CEP 90035-003, Brazil
*
Author to whom correspondence should be addressed.
Received: 20 December 2015 / Revised: 30 January 2016 / Accepted: 2 February 2016 / Published: 10 February 2016
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Abstract

Drug resistance in the treatment of neglected parasitic diseases, such as leishmaniasis and trypanosomiasis, has led to the search and development of alternative drugs from plant origins. In this context, the essential oil extracted by hydro-distillation from Lantana camara leaves was tested against Leishmania braziliensis and Trypanosoma cruzi. The results demonstrated that L. camara essential oil inhibited T. cruzi and L. braziliensis with IC50 of 201.94 μg/mL and 72.31 μg/mL, respectively. L. camara essential oil was found to be toxic to NCTC929 fibroblasts at 500 μg/mL (IC50 = 301.42 μg/mL). The composition of L. camara essential oil analyzed by gas chromatography–mass spectrometry (GC/MS) revealed large amounts of (E)-caryophyllene (23.75%), biciclogermacrene (15.80%), germacrene D (11.73%), terpinolene (6.1%), and sabinene (5.92%), which might be, at least in part, responsible for its activity. Taken together, our results suggest that L. camara essential oil may be an important source of therapeutic agents for the development of alternative drugs against parasitic diseases. View Full-Text
Keywords: Lantana camara; Leishmania braziliensis; Trypanosoma cruzi; essential oil Lantana camara; Leishmania braziliensis; Trypanosoma cruzi; essential oil
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Barros, L.M.; Duarte, A.E.; Morais-Braga, M.F.B.; Waczuk, E.P.; Vega, C.; Leite, N.F.; de Menezes, I.R.A.; Coutinho, H.D.M.; Rocha, J.B.T.; Kamdem, J.P. Chemical Characterization and Trypanocidal, Leishmanicidal and Cytotoxicity Potential of Lantana camara L. (Verbenaceae) Essential Oil. Molecules 2016, 21, 209.

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