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Molecules 2016, 21(2), 176; doi:10.3390/molecules21020176

Metabolites of Siamenoside I and Their Distributions in Rats

1
Guangxi Key Laboratory of Functional Phytochemicals Research and Utilization, Guangxi Institute of Botany, Guangxi Zhuang Autonomous Region and Chinese Academy of Sciences, No. 85, Yanshan Road, Yanshan District, Guilin 541006, China
2
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No. 38 Xueyuan Road, Beijing 100191, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 January 2016 / Revised: 25 January 2016 / Accepted: 27 January 2016 / Published: 30 January 2016
(This article belongs to the Section Metabolites)
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Abstract

Siamenoside I is the sweetest mogroside that has several kinds of bioactivities, and it is also a constituent of Siraitiae Fructus, a fruit and herb in China. Hitherto the metabolism of siamenoside I in human or animals remains unclear. To reveal its metabolic pathways, a high-performance liquid chromatography-electrospray ionization-ion trap-time of flight-multistage mass spectrometry (HPLC-ESI-IT-TOF-MSn) method was used to profile and identify its metabolites in rats. Altogether, 86 new metabolites were identified or tentatively identified, and 23 of them were also new metabolites of mogrosides. In rats, siamenoside I was found to undergo deglycosylation, hydroxylation, dehydrogenation, deoxygenation, isomerization, and glycosylation reactions. Among them, deoxygenation, pentahydroxylation, and didehydrogenation were novel metabolic reactions of mogrosides. The distributions of siamenoside I and its 86 metabolites in rat organs were firstly reported, and they were mainly distributed to intestine, stomach, kidney, and brain. The most widely distributed metabolite was mogroside IIIE. In addition, eight metabolites were bioactive according to literature. These findings would help to understand the metabolism and effective forms of siamenoside I and other mogrosides in vivo. View Full-Text
Keywords: Siraitia grosvenorii; mogrosides; siamenoside I; metabolism; distribution; LC-IT-TOF-MSn; natural sweeteners; saponins; cucurbitanes Siraitia grosvenorii; mogrosides; siamenoside I; metabolism; distribution; LC-IT-TOF-MSn; natural sweeteners; saponins; cucurbitanes
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MDPI and ACS Style

Yang, X.-R.; Xu, F.; Li, D.-P.; Lu, F.-L.; Liu, G.-X.; Wang, L.; Shang, M.-Y.; Huang, Y.-L.; Cai, S.-Q. Metabolites of Siamenoside I and Their Distributions in Rats. Molecules 2016, 21, 176.

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