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Molecules 2016, 21(2), 150; doi:10.3390/molecules21020150

Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities

Department of Pharmacy, Binzhou Medical University Hospital, Yellow River Second Road 661, Binzhou 256603, China
Key Laboratory of Marine Drugs, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Yushan Road 5, Qingdao 266003, China
College of Chemistry and Chemical Engineering, Ocean University of China, Songling Road 238, Qingdao 266100, China
These authors contributed equally to this work.
Authors to whom correspondence should be addressed.
Academic Editor: Fernando Albericio
Received: 25 November 2015 / Revised: 19 January 2016 / Accepted: 21 January 2016 / Published: 26 January 2016
(This article belongs to the Section Natural Products)
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Marine sponges continue to serve as a rich source of alkaloids possessing interesting biological activities and often exhibiting unique structural frameworks. In the current study, chemical investigation on the marine sponge Pericharax heteroraphis collected from the South China Sea yielded one new imidazole alkaloid named naamidine J (1) along with four known ones (25). Their structures were established by extensive spectroscopic methods and comparison of their data with those of the related known compounds. All the isolates possessed a central 2-aminoimidazole ring, substituted by one or two functionalized benzyl groups in some combination of the C4 and C5 positions. The cytotoxicities against selected HL-60, HeLa, A549 and K562 tumor cell lines and anti-H1N1 (Influenza a virus (IAV)) activity for the isolates were evaluated. Compounds 1 and 2 exhibited cytotoxicities against the K562 cell line with IC50 values of 11.3 and 9.4 μM, respectively. Compound 5 exhibited weak anti-H1N1 (influenza a virus, IAV) activity with an inhibition ratio of 33%. View Full-Text
Keywords: sponge; Pericharax heteroraphis; 2-aminoimidazole alkaloids; cytotoxicities; anti-H1N1 activity sponge; Pericharax heteroraphis; 2-aminoimidazole alkaloids; cytotoxicities; anti-H1N1 activity

Figure 1

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Gong, K.-K.; Tang, X.-L.; Liu, Y.-S.; Li, P.-L.; Li, G.-Q. Imidazole Alkaloids from the South China Sea Sponge Pericharax heteroraphis and Their Cytotoxic and Antiviral Activities. Molecules 2016, 21, 150.

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