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Molecules 2016, 21(12), 1755; doi:10.3390/molecules21121755

Polyphenol Composition, Antioxidant Activity and Cytotoxicity of Seeds from Two Underexploited Wild Licania Species: L. rigida and L. tomentosa

Department of Biochemistry and Molecular Biology, Federal University of Ceará, 60020-181 Fortaleza, CE, Brazil
Department of Molecular Biology, Federal University of Paraíba, 58051-900 João Pessoa, PB, Brazil
Health Sciences Center, Federal University of Santa Maria, 97105-900 Santa Maria, RS, Brazil
RIKILT, Wageningen University and Research, P.O. Box 230, 6700 AE Wageningen, The Netherlands
Department of Finance, Federal University of Ceará, 60020-181 Fortaleza, CE, Brazil
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 2 November 2016 / Revised: 14 December 2016 / Accepted: 19 December 2016 / Published: 21 December 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1013 KB, uploaded 21 December 2016]   |  


Studies have shown the benefit of antioxidants in the prevention or treatment of human diseases and promoted a growing interest in new sources of plant antioxidants for pharmacological use. This study aimed to add value to two underexploited wild plant species (Licania rigida) and L. tomentosa) from Brazilian flora. Thus, the phenolic compounds profile of their seed ethanol extract and derived fractions were elucidated by HPLC, the antioxidant capacity was assessed by in vitro chemical tests and the cytotoxicity determined using the human carcinoma cell lines MCF-7 and Caco-2. Eleven phenolic compounds were identified in the extracts of each species. The extracts and fractions showed excellent antioxidant activity in the DPPH assay (SC50, ranging from 9.15 to 248.8 µg/mL). The aqueous fraction of L. rigida seeds was most effective in preventing lipid peroxidation under basal conditions (IC50 60.80 µg/mL) whereas, in the presence of stress inducer, the methanolic fraction of L. tomentosa performed best (IC50 8.55 µg/mL). None of the samples showed iron chelating capacity. Ethanolic seed extracts of both species did not reveal any cytotoxicity against MCF-7 and Caco-2 cells. Both plant species showed a promising phenolic profile with potent antioxidant capacity and deserve attention to be sustainably explored. View Full-Text
Keywords: MCF-7; Caco-2; DPPH; TBARS; phenolic compound; cytotoxicity MCF-7; Caco-2; DPPH; TBARS; phenolic compound; cytotoxicity

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Parra Pessoa, I.; Lopes Neto, J.J.; Silva de Almeida, T.; Felipe Farias, D.; Vieira, L.R.; Lima de Medeiros, J.; Augusti Boligon, A.; Peijnenburg, A.; Castelar, I.; Fontenele Urano Carvalho, A. Polyphenol Composition, Antioxidant Activity and Cytotoxicity of Seeds from Two Underexploited Wild Licania Species: L. rigida and L. tomentosa. Molecules 2016, 21, 1755.

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