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Molecules 2016, 21(12), 1749; doi:10.3390/molecules21121749

New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities

1
The MOE Key Laboratory of Standardization of Chinese Medicines, and SATCM Key Laboratory of New Resources and Quality Evaluation of Chinese Medicines, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, Shanghai 201210, China
2
Shanghai R&D Center for Standardization of Chinese Medicines, Shanghai 201203, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 October 2016 / Revised: 1 December 2016 / Accepted: 9 December 2016 / Published: 21 December 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1331 KB, uploaded 22 December 2016]   |  

Abstract

In our continued investigations of the plant Caryopteris incana, five new iridoid glucosides 15, including two cis-trans-isomers, 3 and 4, along with six known compounds 611, were isolated from the n-butyl alcohol (n-BuOH) soluble fraction of whole dried material of Caryopteris incana. Their structures were established by a combination of spectroscopic techniques, including 1D and 2D NMR and high resolution electrospray ionization mass spectroscopy (HR-ESI-MS). Furthermore, all isolates were evaluated for their yeast α-glucosidase inhibitory effects. Among these compounds, 48 and 10 exhibited potent inhibition of α-glucosidase. View Full-Text
Keywords: Caryopteris incana; iridoid glucosides; type-II diabetes mellitus; α-glucosidase inhibition Caryopteris incana; iridoid glucosides; type-II diabetes mellitus; α-glucosidase inhibition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Mao, X.-D.; Chou, G.-X.; Zhao, S.-M.; Zhang, C.-G. New Iridoid Glucosides from Caryopteris incana (Thunb.) Miq. and Their α-Glucosidase Inhibitory Activities. Molecules 2016, 21, 1749.

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