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Molecules 2016, 21(12), 1754; doi:10.3390/molecules21121754

Chemical Fingerprint Analysis and Quantitative Analysis of Rosa rugosa by UPLC-DAD

1
Key Laboratory of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
2
Key Laboratory of Plant Resources and Chemistry in Arid Regions, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi 830011, China
3
University of Chinese Academy of Sciences, Beijing 100049, China
*
Author to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 14 October 2016 / Revised: 25 November 2016 / Accepted: 13 December 2016 / Published: 21 December 2016
(This article belongs to the Section Natural Products)
View Full-Text   |   Download PDF [1648 KB, uploaded 21 December 2016]   |  

Abstract

A method based on ultra performance liquid chromatography with a diode array detector (UPLC-DAD) was developed for quantitative analysis of five active compounds and chemical fingerprint analysis of Rosa rugosa. Ten batches of R. rugosa collected from different plantations in the Xinjiang region of China were used to establish the fingerprint. The feasibility and advantages of the used UPLC fingerprint were verified for its similarity evaluation by systematically comparing chromatograms with professional analytical software recommended by State Food and Drug Administration (SFDA) of China. In quantitative analysis, the five compounds showed good regression (R2 = 0.9995) within the test ranges, and the recovery of the method was in the range of 94.2%–103.8%. The similarities of liquid chromatography fingerprints of 10 batches of R. rugosa were more than 0.981. The developed UPLC fingerprint method is simple, reliable, and validated for the quality control and identification of R. rugosa. Additionally, simultaneous quantification of five major bioactive ingredients in the R. rugosa samples was conducted to interpret the consistency of the quality test. The results indicated that the UPLC fingerprint, as a characteristic distinguishing method combining similarity evaluation and quantification analysis, can be successfully used to assess the quality and to identify the authenticity of R. rugosa. View Full-Text
Keywords: Rosa rugosa; UPLC-DAD; quality control; fingerprint Rosa rugosa; UPLC-DAD; quality control; fingerprint
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Mansur, S.; Abdulla, R.; Ayupbec, A.; Aisa, H.A. Chemical Fingerprint Analysis and Quantitative Analysis of Rosa rugosa by UPLC-DAD. Molecules 2016, 21, 1754.

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