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Molecules 2016, 21(12), 1725; doi:10.3390/molecules21121725

Half-Sandwich Ru(II) Halogenido, Valproato and 4-Phenylbutyrato Complexes Containing 2,2′-Dipyridylamine: Synthesis, Characterization, Solution Chemistry and In Vitro Cytotoxicity

1
Department of Inorganic Chemistry & Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University in Olomouc, 17. listopadu 12, 771 46 Olomouc, Czech Republic
2
Department of Cell Biology and Genetics & Regional Centre of Advanced Technologies and Materials, Faculty of Science, Palacký University in Olomouc, Šlechtitelů 27, 783 71 Olomouc, Czech Republic
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 9 November 2016 / Revised: 12 December 2016 / Accepted: 13 December 2016 / Published: 15 December 2016
(This article belongs to the Section Organometallic Chemistry)
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Abstract

Halogenido and carboxylato Ru(II) half-sandwich complexes of the general composition [Ru(η6-p-cym)(dpa)X]PF6 (15) were prepared and thoroughly characterized with various techniques (e.g., mass spectrometry, NMR spectroscopy and X-ray analysis); dpa = 2,2′-dipyridylamine; p-cym = p-cymene; X = Cl (for 1), Br (for 2), I (for 3), valproate(1−) (for 4) or 4-phenylbutyrate(1−) (for 5). A single-crystal X-ray analysis showed a pseudo-octahedral piano-stool geometry of [Ru(η6-p-cym)(dpa)I]PF6 (3), with a η6-coordinated p-cymene, bidentate N-donor dpa ligand and iodido ligand coordinated to the Ru(II) atom. The results of the 1H-NMR solution behaviour studies proved that the complexes 15 hydrolyse were in the mixture of solvents used (10% MeOD-d4/90% D2O). Complexes 15 were in vitro inactive against the A2780 human ovarian carcinoma cell line, up to the highest tested concentration (IC50 > 100 μM). View Full-Text
Keywords: ruthenium; half-sandwich; 2,2′-dipyridylamine; X-ray structure; solution behaviour; in vitro cytotoxicity ruthenium; half-sandwich; 2,2′-dipyridylamine; X-ray structure; solution behaviour; in vitro cytotoxicity
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Štarha, P.; Trávníček, Z.; Křikavová, R.; Dvořák, Z. Half-Sandwich Ru(II) Halogenido, Valproato and 4-Phenylbutyrato Complexes Containing 2,2′-Dipyridylamine: Synthesis, Characterization, Solution Chemistry and In Vitro Cytotoxicity. Molecules 2016, 21, 1725.

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