Next Article in Journal
Photostability and Performance of Polystyrene Films Containing 1,2,4-Triazole-3-thiol Ring System Schiff Bases
Next Article in Special Issue
Design and Experimental Evolution of trans-Splicing Group I Intron Ribozymes
Previous Article in Journal
Methotrexate and Cytarabine—Loaded Nanocarriers for Multidrug Cancer Therapy. Spectroscopic Study
Previous Article in Special Issue
Many Activities, One Structure: Functional Plasticity of Ribozyme Folds
Article Menu
Issue 12 (December) cover image

Export Article

Open AccessArticle
Molecules 2016, 21(12), 1701; doi:10.3390/molecules21121701

Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World?

1
Institute for Advanced Studies in Theoretical Chemistry, Schulich Faculty of Chemistry–Technion–Israel Institute of Technology, Haifa 32000, Israel
2
Fritz Haber Research Center for Molecular Dynamics, Hebrew University of Jerusalem, Jerusalem 91904, Israel
Academic Editor: Sabine Müller
Received: 20 September 2016 / Revised: 21 November 2016 / Accepted: 24 November 2016 / Published: 9 December 2016
(This article belongs to the Special Issue Ribozymes and RNA Catalysis)
View Full-Text   |   Download PDF [1071 KB, uploaded 14 December 2016]   |  

Abstract

An indispensable prerequisite for establishing a scenario of life emerging by natural processes is the requirement that the first simple proto-molecules could have had a realistic probability of self-assembly from random molecular polymers in the prebiotic world. The vestige of the proto-ribosome, which is believed to be still embedded in the contemporary ribosome, is used to assess the feasibility of such spontaneous emergence. Three concentric structural elements of different magnitudes, having a dimeric nature derived from the symmetrical region of the ribosomal large subunit, were suggested to constitute the vestige of the proto-ribosome. It is assumed to have materialized spontaneously in the prebiotic world, catalyzing non-coded peptide bond formation and simple elongation. Probabilistic and energetic considerations are applied in order to evaluate the suitability of the three contenders for being the initial proto-ribosome. The analysis points to the simplest proto-ribosome, comprised of a dimer of tRNA-like molecules presently embedded in the core of the symmetrical region, as the only one having a realistic statistical likelihood of spontaneous emergence from random RNA chains. Hence it offers a feasible starting point for a continuous evolutionary path from the prebiotic matter, through natural processes, into the intricate modern translation system. View Full-Text
Keywords: ribosome; proto-ribosome; ribosome symmetrical region; RNA world; origin of life ribosome; proto-ribosome; ribosome symmetrical region; RNA world; origin of life
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Agmon, I.C. Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World? Molecules 2016, 21, 1701.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top