Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World?
AbstractAn indispensable prerequisite for establishing a scenario of life emerging by natural processes is the requirement that the first simple proto-molecules could have had a realistic probability of self-assembly from random molecular polymers in the prebiotic world. The vestige of the proto-ribosome, which is believed to be still embedded in the contemporary ribosome, is used to assess the feasibility of such spontaneous emergence. Three concentric structural elements of different magnitudes, having a dimeric nature derived from the symmetrical region of the ribosomal large subunit, were suggested to constitute the vestige of the proto-ribosome. It is assumed to have materialized spontaneously in the prebiotic world, catalyzing non-coded peptide bond formation and simple elongation. Probabilistic and energetic considerations are applied in order to evaluate the suitability of the three contenders for being the initial proto-ribosome. The analysis points to the simplest proto-ribosome, comprised of a dimer of tRNA-like molecules presently embedded in the core of the symmetrical region, as the only one having a realistic statistical likelihood of spontaneous emergence from random RNA chains. Hence it offers a feasible starting point for a continuous evolutionary path from the prebiotic matter, through natural processes, into the intricate modern translation system. View Full-Text
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Agmon, I.C. Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World? Molecules 2016, 21, 1701.
Agmon IC. Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World? Molecules. 2016; 21(12):1701.Chicago/Turabian Style
Agmon, Ilana C. 2016. "Could a Proto-Ribosome Emerge Spontaneously in the Prebiotic World?" Molecules 21, no. 12: 1701.
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