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Molecules 2016, 21(11), 1601; doi:10.3390/molecules21111601

Damxungmacin A and B, Two New Amicoumacins with Rare Heterocyclic Cores Isolated from Bacillus subtilis XZ-7

School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
School of Pharmacy, Jiangsu Food & Pharmaceutical Science College, Huaian 223005, Jiangsu, China
Authors to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 12 October 2016 / Revised: 13 November 2016 / Accepted: 20 November 2016 / Published: 23 November 2016
(This article belongs to the Section Natural Products)
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Two new amicoumacins, named Damxungmacin A (1) and B (2), were isolated from the culture broth of a soil-derived bacterium Bacillus subtilis XZ-7. Their chemical structures were elucidated by spectroscopic studies (UV, IR, NMR and HR-ESI-MS). Compound 1 possessed a 1,4-diazabicyclo[2.2.1]heptane-2-one ring system in its structure, which was reported for the first time, while 2 had a 1-acetylmorpholine-3-one moiety, which was naturally rare. Compound 1 exhibited moderate to weak cytotoxic activities against three human tumor cell lines (A549, HCT116 and HepG2) with IC50 values of 13.33, 14.34 and 13.64 μM, respectively. Meanwhile, compound 1 showed weak antibacterial activities against some strains of Staphylococcus epidermidis, while compound 2 at 16 μg/mL did not show antibacterial activity. View Full-Text
Keywords: Damxungmacin; amicoumacins; Bacillus subtilis; antibacterial activity; cytotoxic activity Damxungmacin; amicoumacins; Bacillus subtilis; antibacterial activity; cytotoxic activity

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Tang, H.-L.; Sun, C.-H.; Hu, X.-X.; You, X.-F.; Wang, M.; Liu, S.-W. Damxungmacin A and B, Two New Amicoumacins with Rare Heterocyclic Cores Isolated from Bacillus subtilis XZ-7. Molecules 2016, 21, 1601.

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