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Molecules 2016, 21(11), 1601; doi:10.3390/molecules21111601

Damxungmacin A and B, Two New Amicoumacins with Rare Heterocyclic Cores Isolated from Bacillus subtilis XZ-7

1
School of Life Science and Technology, China Pharmaceutical University, Nanjing 210009, Jiangsu, China
2
Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
3
School of Pharmacy, Jiangsu Food & Pharmaceutical Science College, Huaian 223005, Jiangsu, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Thomas J. Schmidt
Received: 12 October 2016 / Revised: 13 November 2016 / Accepted: 20 November 2016 / Published: 23 November 2016
(This article belongs to the Section Natural Products)
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Abstract

Two new amicoumacins, named Damxungmacin A (1) and B (2), were isolated from the culture broth of a soil-derived bacterium Bacillus subtilis XZ-7. Their chemical structures were elucidated by spectroscopic studies (UV, IR, NMR and HR-ESI-MS). Compound 1 possessed a 1,4-diazabicyclo[2.2.1]heptane-2-one ring system in its structure, which was reported for the first time, while 2 had a 1-acetylmorpholine-3-one moiety, which was naturally rare. Compound 1 exhibited moderate to weak cytotoxic activities against three human tumor cell lines (A549, HCT116 and HepG2) with IC50 values of 13.33, 14.34 and 13.64 μM, respectively. Meanwhile, compound 1 showed weak antibacterial activities against some strains of Staphylococcus epidermidis, while compound 2 at 16 μg/mL did not show antibacterial activity. View Full-Text
Keywords: Damxungmacin; amicoumacins; Bacillus subtilis; antibacterial activity; cytotoxic activity Damxungmacin; amicoumacins; Bacillus subtilis; antibacterial activity; cytotoxic activity
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Tang, H.-L.; Sun, C.-H.; Hu, X.-X.; You, X.-F.; Wang, M.; Liu, S.-W. Damxungmacin A and B, Two New Amicoumacins with Rare Heterocyclic Cores Isolated from Bacillus subtilis XZ-7. Molecules 2016, 21, 1601.

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