Next Article in Journal
Chiral Hypervalent, Pentacoordinated Phosphoranes
Next Article in Special Issue
Multi-Functional Nanogels for Tumor Targeting and Redox-Sensitive Drug and siRNA Delivery
Previous Article in Journal / Special Issue
Carbon-Based Materials for Photo-Triggered Theranostic Applications
Article Menu
Issue 11 (November) cover image

Export Article

Open AccessReview
Molecules 2016, 21(11), 1580; doi:10.3390/molecules21111580

A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering

Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, 7 York Road, Parktown 2193, South Africa
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 19 September 2016 / Revised: 24 October 2016 / Accepted: 16 November 2016 / Published: 21 November 2016
(This article belongs to the Special Issue Stimuli-Responsive Biomaterials in Biomedical Applications)
View Full-Text   |   Download PDF [2148 KB, uploaded 21 November 2016]   |  

Abstract

Biodegradable, stimuli-responsive polymers are essential platforms in the field of drug delivery and injectable biomaterials for application of bone tissue engineering. Various thermo-responsive hydrogels display water-based homogenous properties to encapsulate, manipulate and transfer its contents to the surrounding tissue, in the least invasive manner. The success of bioengineered injectable tissue modified delivery systems depends significantly on their chemical, physical and biological properties. Irrespective of shape and defect geometry, injectable therapy has an unparalleled advantage in which intricate therapy sites can be effortlessly targeted with minimally invasive procedures. Using material testing, it was found that properties of stimuli-responsive hydrogel systems enhance cellular responses and cell distribution at any site prior to the transitional phase leading to gelation. The substantially hydrated nature allows significant simulation of the extracellular matrix (ECM), due to its similar structural properties. Significant current research strategies have been identified and reported to date by various institutions, with particular attention to thermo-responsive hydrogel delivery systems, and their pertinent focus for bone tissue engineering. Research on future perspective studies which have been proposed for evaluation, have also been reported in this review, directing considerable attention to the modification of delivering natural and synthetic polymers, to improve their biocompatibility and mechanical properties. View Full-Text
Keywords: biodegradable; thermo-responsive polymers; hydrogels; tissue engineering; drug delivery; stimuli-responsive biodegradable; thermo-responsive polymers; hydrogels; tissue engineering; drug delivery; stimuli-responsive
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Kondiah, P.J.; Choonara, Y.E.; Kondiah, P.P.D.; Marimuthu, T.; Kumar, P.; du Toit, L.C.; Pillay, V. A Review of Injectable Polymeric Hydrogel Systems for Application in Bone Tissue Engineering. Molecules 2016, 21, 1580.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top