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Molecules 2016, 21(11), 1547; doi:10.3390/molecules21111547

Fractional CO2 Laser Pretreatment Facilitates Transdermal Delivery of Two Vitamin C Derivatives

1
Department of Nutrition and Health Sciences, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
2
Research Center for Industry of Human Ecology and Research Center for Chinese Herbal Medicine, College of Human Ecology, Chang Gung University of Science and Technology, Taoyuan 33301, Taiwan
3
Aesthetic Medical Center, Department of Dermatology, Chang Gung Memorial Hospital, Taoyuan 333, Taiwan
4
Department of Anatomy, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
5
College of Medicine, Chang Gung University, Taoyuan 333, Taiwan
6
Department of Cosmetic Science, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Yogeshvar N. Kalia
Received: 19 July 2016 / Revised: 28 October 2016 / Accepted: 10 November 2016 / Published: 16 November 2016
(This article belongs to the Special Issue Transdermal Delivery Systems: Current Landscape and Trends)
View Full-Text   |   Download PDF [2990 KB, uploaded 16 November 2016]   |  

Abstract

Background: Topical vitamin C derivatives have been used to treat melasma and used as a skin whitener. The aim of this study was to compare skin histology and permeation of l-ascorbic acid 2-phosphate sesquimagnesium salt (MAP-1) and magnesium l-ascorbic acid-2-phosphate (MAP-2) after fractional CO2 laser pretreatment. Methods: The effect of fractional laser treatment on porcine skin was examined by scanning electron microscopy and confocal laser scanning electron microscopy. The effect of fractional CO2 laser treatment of different fluencies and pass numbers on transdermal flux of the two vitamin C derivatives through porcine skin was examined in vitro using a Franz diffusion chamber. Results: Fluxes of MAP-1 and MAP-2 across fractional CO2 laser-treated (5 W) skin were eight- to 13-fold, and 20- to 22-fold higher, respectively, than the fluxes of these compounds across intact skin. Fluxes of MAP-1 and MAP-2 across fractional CO2 laser-treated (9 W) skin were 14- to 19-fold, and 30- to 42-fold higher, respectively, than their fluxes across intact skin. Conclusion: Fractional CO2 laser treatment is an effective way of delivering vitamin C derivatives into the skin. View Full-Text
Keywords: vitamin C derivatives; fractional CO2 laser; transdermal delivery vitamin C derivatives; fractional CO2 laser; transdermal delivery
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MDPI and ACS Style

Hsiao, C.-Y.; Sung, H.-C.; Hu, S.; Huang, Y.-L.; Huang, C.-H. Fractional CO2 Laser Pretreatment Facilitates Transdermal Delivery of Two Vitamin C Derivatives. Molecules 2016, 21, 1547.

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