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Molecules 2016, 21(11), 1419; doi:10.3390/molecules21111419

Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota

1
Institute of Food Sciences and Technology, National Taiwan University, Taipei 10617, Taiwan
2
Department of Biological Science & Technology, China Medical University, Taichung 40402, Taiwan
3
Department of Tourism, Food and Beverage Management, Chang Jung Christian University, Tainan 71101, Taiwan
4
Sabinsa Corporation, East Windsor, NJ 08520, USA
5
Department of Food Science, Rutgers University, New Brunswick, NJ 08901, USA
6
Department of Medical Research, China Medical University Hospital, China Medical University, Taichung 40402, Taiwan
7
Department of Health and Nutrition Biotechnology, Asia University, Taichung 41354, Taiwan
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 September 2016 / Revised: 20 October 2016 / Accepted: 21 October 2016 / Published: 25 October 2016
(This article belongs to the Special Issue Natural Products in Anti-Obesity Therapy)
View Full-Text   |   Download PDF [4020 KB, uploaded 25 October 2016]   |  

Abstract

Obesity is a global health concern. Piceatannol (Pic), an analog of resveratrol (Res), has many reported biological activities. In this study, we investigated the anti-obesity effect of Pic in a high-fat diet (HFD)-induced obese animal model. The results showed that Pic significantly reduced mouse body weight in a dose-dependent manner without affecting food intake. Serum total cholesterol (TC), low-density lipoprotein (LDL), high-density lipoprotein (HDL) levels, and blood glucose (GLU) were significantly lowered in Pic-treated groups. Pic significantly decreased the weight of liver, spleen, perigonadal and retroperitoneal fat compared with the HFD group. Pic significantly reduced the adipocyte cell size of perigonadal fat and decreased the weight of liver. Pic-treated mice showed higher phosphorylated adenosine 5′-monophosphate-activated protein kinase (pAMPK) and phosphorylated acetyl-CoA carboxylase (pACC) protein levels and decreased protein levels of CCAAT/enhancer-binding protein C/EBPα, peroxisome proliferator-activated receptor PPARγ and fatty acid synthase (FAS), resulting in decreased lipid accumulation in adipocytes and the liver. Pic altered the composition of the gut microbiota by increasing Firmicutes and Lactobacillus and decreasing Bacteroidetes compared with the HFD group. Collectively, these results suggest that Pic may be a candidate for obesity treatment. View Full-Text
Keywords: obesity; piceatannol; high-fat diet; C57BL/6; AMPK; gut microbiota obesity; piceatannol; high-fat diet; C57BL/6; AMPK; gut microbiota
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MDPI and ACS Style

Tung, Y.-C.; Lin, Y.-H.; Chen, H.-J.; Chou, S.-C.; Cheng, A.-C.; Kalyanam, N.; Ho, C.-T.; Pan, M.-H. Piceatannol Exerts Anti-Obesity Effects in C57BL/6 Mice through Modulating Adipogenic Proteins and Gut Microbiota. Molecules 2016, 21, 1419.

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