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Molecules 2016, 21(10), 1404; doi:10.3390/molecules21101404

Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity

1
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS) I-87036, Italy
2
Department of AGRARIA, University “Mediterranea” of Reggio Calabria, Reggio Calabria (RC) I-89124, Italy
*
Author to whom correspondence should be addressed.
Academic Editors: Min-Hsiung Pan and Filomena Conforti
Received: 3 August 2016 / Revised: 11 October 2016 / Accepted: 12 October 2016 / Published: 20 October 2016
(This article belongs to the Special Issue Natural Products in Anti-Obesity Therapy)
View Full-Text   |   Download PDF [2258 KB, uploaded 20 October 2016]   |  

Abstract

Obesity is one of the greatest public health problems. This complex condition has reached epidemic proportions in many parts of the world, and it constitutes a risk factor for several chronic disorders, such as hypertension, cardiovascular diseases and type 2 diabetes. In the last few decades, several studies dealt with the potential effects of natural products as new safe and effective tools for body weight control. Saponins are naturally-occurring surface-active glycosides, mainly produced by plants, whose structure consists of a sugar moiety linked to a hydrophobic aglycone (a steroid or a triterpene). Many pharmacological properties have been reported for these compounds, such as anti-inflammatory, immunostimulant, hypocholesterolemic, hypoglycemic, antifungal and cytotoxic activities. The aim of this review is to provide an overview of recent studies about the anti-obesity therapeutic potential of saponins isolated from medicinal plants. Results on the in vitro and in vivo activity of this class of phytochemicals are here presented and discussed. The most interesting findings about their possible mechanism of action and their potential health benefits in the treatment of obesity are reported, as well. View Full-Text
Keywords: lipid metabolism; medicinal plant; obesity; phytochemicals; saponins lipid metabolism; medicinal plant; obesity; phytochemicals; saponins
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Marrelli, M.; Conforti, F.; Araniti, F.; Statti, G.A. Effects of Saponins on Lipid Metabolism: A Review of Potential Health Benefits in the Treatment of Obesity. Molecules 2016, 21, 1404.

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