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Molecules 2016, 21(10), 1397; doi:10.3390/molecules21101397

Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum

Laboratory of Natural Products Pesticides, College of Plant Protection, Southwest University, Chongqing 400715, China
These two authors contributed equally to this work.
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Author to whom correspondence should be addressed.
Academic Editor: Peter J. Rutledge
Received: 8 September 2016 / Revised: 10 October 2016 / Accepted: 15 October 2016 / Published: 19 October 2016
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Abstract

Many cereals accumulate hydroxamic acids involved in defense of plant against various fungi, bacteria, and insects. 2,4-dihydroxy-7-methoxy-1,4-benzoxazine-3-one, commonly known as DIMBOA, is one of the principal cyclic hydroxamic acids in aqueous extracts of maize. The aim of this study was to evaluate the antibacterial activity of the isolated DIMBOA and its derivatives 2-benzoxazolinone (BOA), 6-chloro-2-benzoxazolinone (CDHB), and 2-mercaptobenzothiazole (MBT) against Ralstonia solanacearum. MBT showed the strongest antibacterial activity, followed by CDHB and DIMBOA, with minimum inhibitory concentrations (MICs) of 50, 100 and 200 mg/L, respectively, better than the BOA with 300 mg/L. These compounds also significantly affect bacterial growth, reduce biofilm formation, and inhibit swarming motility within 24 h. This paper is the first to report the anti-R. solanacearum activity of DIMBOA from Z. mays. The bioassay and pot experiment results suggested that DIMBOA and its derivatives exhibit potential as a new matrix structure of designing target bactericide or elicitor for controlling tobacco bacterial wilt. Further studies must evaluate the efficacy of DIMBOA and its derivatives in controlling bacterial wilt under natural field conditions where low inoculum concentrations exist. View Full-Text
Keywords: DIMBOA; Ralstonia solanacearum; antibacterial activity; biofilm inhibition; bacterial wilt DIMBOA; Ralstonia solanacearum; antibacterial activity; biofilm inhibition; bacterial wilt
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MDPI and ACS Style

Guo, B.; Zhang, Y.; Li, S.; Lai, T.; Yang, L.; Chen, J.; Ding, W. Extract from Maize (Zea mays L.): Antibacterial Activity of DIMBOA and Its Derivatives against Ralstonia solanacearum. Molecules 2016, 21, 1397.

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