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Molecules 2016, 21(11), 1562; doi:10.3390/molecules21111562

Antimicrobial Activity of Zabofloxacin against Clinically Isolated Streptococcus pneumoniae

1
School of Food Science and Biotechnology, Kyungpook National University, Daegu 41566, Korea
2
School of Life Science, Handong Global University, 558 Handong-ro, Buk-gu, Pohang 37554, Korea
3
Dong Wha Pharm., Ind. Co. Ltd., Anyang 31041, Korea
These authors contributed equally to this work.
*
Author to whom correspondence should be addressed.
Academic Editor: Diego Muñoz-Torrero
Received: 15 September 2016 / Revised: 1 November 2016 / Accepted: 9 November 2016 / Published: 17 November 2016
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Abstract

Zabofloxacin is a novel fluoroquinolone agent that has potent activity against gram-positive pathogens. In this study, we confirmed that zabofloxacin showed the most potent in vitro and in vivo activities against drug-resistant Streptococcus pneumoniae. Among the fluoroquinolone compounds, zabofloxacin showed the most potent in vitro activity against clinical isolates of penicillin-sensitive S. pneumoniae (minimum inhibitory concentration, MIC90: 0.03 mg/L) and penicillin-resistant S. pneumoniae (MIC90: 0.03 mg/L). Against quinolone-resistant S. pneumoniae, zabofloxacin (MIC90: 1 mg/L) was more active than ciprofloxacin, sparfloxacin, and moxifloxacin; however, its activity was the same as that of gemifloxacin. The in vivo activity of zabofloxacin was most potent among the quinolone compounds tested against the systemic infection and respiratory tract infection models in mice. View Full-Text
Keywords: zabofloxacin; minimum inhibitory concentration; Streptococcus pneumoniae; in vivo zabofloxacin; minimum inhibitory concentration; Streptococcus pneumoniae; in vivo
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Park, H.-S.; Oh, S.-H.; Kim, H.-S.; Choi, D.-R.; Kwak, J.-H. Antimicrobial Activity of Zabofloxacin against Clinically Isolated Streptococcus pneumoniae. Molecules 2016, 21, 1562.

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