Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action
AbstractFungal pathogens continue to pose challenges to humans and plants despite efforts to control them. Two coumarins, robustic acid and thonningine-C isolated from Millettia thonningii, show promising activity against the fungus Candida albicans with minimum fungicidal concentration of 1.0 and 0.5 mg/mL, respectively. Molecular modelling against the putative bio-molecular target, lanosterol 14α-demethylase (CYP51), revealed a plausible binding mode for the active compounds, in which the hydroxyl group binds with a methionine backbone carboxylic group blocking access to the iron catalytic site. This binding disrupts the synthesis of several important sterols for the survival of fungi. View Full-Text
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Ayine-Tora, D.M.; Kingsford-Adaboh, R.; Asomaning, W.A.; Harrison, J.J.; Mills-Robertson, F.C.; Bukari, Y.; Sakyi, P.O.; Kaminta, S.; Reynisson, J. Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action. Molecules 2016, 21, 1369.
Ayine-Tora DM, Kingsford-Adaboh R, Asomaning WA, Harrison JJ, Mills-Robertson FC, Bukari Y, Sakyi PO, Kaminta S, Reynisson J. Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action. Molecules. 2016; 21(10):1369.Chicago/Turabian Style
Ayine-Tora, Daniel M.; Kingsford-Adaboh, Robert; Asomaning, William A.; Harrison, Jerry J.; Mills-Robertson, Felix C.; Bukari, Yahaya; Sakyi, Patrick O.; Kaminta, Sylvester; Reynisson, Jóhannes. 2016. "Coumarin Antifungal Lead Compounds from Millettia thonningii and Their Predicted Mechanism of Action." Molecules 21, no. 10: 1369.
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