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Molecules 2016, 21(10), 1361; doi:10.3390/molecules21101361

Three New Butenolides from the Fungus Aspergillus sp. CBS-P-2

School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China
Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China
Department of Medicinal Chemistry, School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang 110016, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 10 September 2016 / Revised: 9 October 2016 / Accepted: 10 October 2016 / Published: 13 October 2016
View Full-Text   |   Download PDF [887 KB, uploaded 13 October 2016]   |  


Three new butenolides aspernolides H–J (13) together with seven known ones (410) were isolated from the fungus Aspergillus sp. CBS-P-2. Their chemical structures were established on the basis of 1D- and 2D-NMR spectroscopic data, HR-ESI-MS analysis, and their absolute configuration were determined by circular dichroism (CD) analysis. All the compounds were evaluated for the antioxidant effects by DPPH and ABTS methods, the antitumor activities against four human tumor cell lines (HL-60, ASPC1, HCT-116 and PC-3) and antimicrobial activities. Compounds 410 showed significant activity against DPPH (IC50 = 15.9–34.3 μM) and compounds 110 exhibited significant ABTS free radical scavenging activity (IC50 = 2.8–33.1 μM). Compounds 2, 5 and 11 showed potent cytotoxic activities against HL-60 cell lines with IC50 values of 39.4, 13.2 and 16.3 μM, respectively. Compound 10 showed good antimicrobial activity against Staphylococcus aureus with minimum inhibitory concentration (MIC) of 21.3 μM. View Full-Text
Keywords: Aspergillus sp.; butenolides; antioxidation; cytotoxicity; antimicrobial activity Aspergillus sp.; butenolides; antioxidation; cytotoxicity; antimicrobial activity

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MDPI and ACS Style

An, X.; Pei, Y.; Chen, S.; Li, S.; Hu, X.; Chen, G.; Lin, B.; Wang, H. Three New Butenolides from the Fungus Aspergillus sp. CBS-P-2. Molecules 2016, 21, 1361.

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