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Molecules 2016, 21(10), 1356; doi:10.3390/molecules21101356

Mitoxantrone-Surfactant Interactions: A Physicochemical Overview

1
Institute of Physical Chemistry Ilie Murgulescu, Romanian Academy, Splaiul Independentei 202, Bucharest 060021, Romania
2
Institute of Biology Bucharest, Romanian Academy, Splaiul Independentei 296, Bucharest 060031, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 1 September 2016 / Revised: 29 September 2016 / Accepted: 1 October 2016 / Published: 13 October 2016
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Abstract

Mitoxantrone is a synthetic anticancer drug used clinically in the treatment of different types of cancer. It was developed as a doxorubicin analogue in a program to find drugs with improved antitumor activity and decreased cardiotoxicity compared with the anthracyclines. As the cell membrane is the first barrier encountered by anticancer drugs before reaching the DNA sites inside the cells and as surfactant micelles are known as simple model systems for biological membranes, the drugs-surfactant interaction has been the subject of great research interest. Further, quantitative understanding of the interactions of drugs with biomimicking structures like surfactant micelles may provide helpful information for the control of physicochemical properties and bioactivities of encapsulated drugs in order to design better delivery systems with possible biomedical applications. The present review describes the physicochemical aspects of the interactions between the anticancer drug mitoxantrone and different surfactants. Mitoxantrone-micelle binding constants, partitions coefficient of the drug between aqueous and micellar phases and the corresponding Gibbs free energy for the above processes, and the probable location of drug molecules in the micelles are discussed. View Full-Text
Keywords: mitoxantrone; surfactants; micelles; binding constant; partition coefficient mitoxantrone; surfactants; micelles; binding constant; partition coefficient
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Enache, M.; Toader, A.M.; Enache, M.I. Mitoxantrone-Surfactant Interactions: A Physicochemical Overview. Molecules 2016, 21, 1356.

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