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Molecules 2016, 21(10), 1308; doi:10.3390/molecules21101308

Re-188 Enhances the Inhibitory Effect of Bevacizumab in Non-Small-Cell Lung Cancer

Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Shanghai Institute of Medical Imaging, Shanghai 200032, China
Departments of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 200032, China
These authors contributed equally to this work.
Author to whom correspondence should be addressed.
Academic Editor: Zhen Cheng
Received: 18 July 2016 / Revised: 24 September 2016 / Accepted: 25 September 2016 / Published: 30 September 2016
(This article belongs to the Special Issue Molecular Imaging Probes)
View Full-Text   |   Download PDF [10698 KB, uploaded 30 September 2016]   |  


The malignant behaviors of solid tumors such as growth, infiltration and metastasis are mainly nourished by tumor neovascularization. Thus, anti-angiogenic therapy is key to controlling tumor progression. Bevacizumab, a humanized anti-vascular endothelial growth factor (VEGF) antibody, plus chemotherapy or biological therapy can prolong survival for cancer patients, but treatment-related mortality is a concern. To improve inhibitory effect and decrease side-effects on non-small-cell lung cancer (NSCLC), we used Re-188, which is a β emitting radionuclide, directly labeled with bevacizumab for radioimmunotherapy in a human A549 tumor model. Cytotoxic assay data showed that, after 188ReO4 or 188Re-bevacizumab at different concentration for 4 and 24 h, a time- and radioactivity does-dependent reduction in cell viability occurred. Also, an apoptosis assay conformed great apoptosis in the 188Re-bevacizumab group compared with controls and other treatment groups. In vivo, tumor volumes in the 188Re-bevacizumab (11.1 MBq/mice) group were not reduced but growth was delayed compared with other groups. Thus, 188Re-bevacizumab enhanced the therapeutic effect of bevacizumab, suggesting a potential therapeutic strategy for NSCLC treatment. View Full-Text
Keywords: bevacizumab; non-small cell lung cancer; radioimmunotherapy; Re-188; Tc-99m bevacizumab; non-small cell lung cancer; radioimmunotherapy; Re-188; Tc-99m

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Xiao, J.; Xu, X.; Li, X.; Li, Y.; Liu, G.; Tan, H.; Shen, H.; Shi, H.; Cheng, D. Re-188 Enhances the Inhibitory Effect of Bevacizumab in Non-Small-Cell Lung Cancer. Molecules 2016, 21, 1308.

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