Next Article in Journal
Re-188 Enhances the Inhibitory Effect of Bevacizumab in Non-Small-Cell Lung Cancer
Next Article in Special Issue
Special Issue “Potential Neuromodulatory Profile of Phytocompounds in Brain Disorders”
Previous Article in Journal
Growing and Etching MoS2 on Carbon Nanotube Film for Enhanced Electrochemical Performance
Previous Article in Special Issue
Chlorella sorokiniana Extract Improves Short-Term Memory in Rats
Article Menu
Issue 10 (October) cover image

Export Article

Open AccessReview
Molecules 2016, 21(10), 1312; doi:10.3390/molecules21101312

Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role?

1
Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, viale Annunziata, Messina I-98168, Italy
2
Department of Health Sciences, University “Magna Graecia” of Catanzaro, Catanzaro I-88100, Italy
3
Department of Biotechnology and Legal Medicine, University of Palermo, Palermo I-90127, Italy
4
Department of Clinical and Experimental Medicine, University of Messina, Messina I-98125, Italy
5
Institute of Applied Sciences and Intelligent Systems (ISASI), National Research Council (CNR), Pozzuoli I-80078, Italy
6
Department of Biomedical and Dental Sciences and Morphofunctional Imaging, University of Messina, Messina I-98125, Italy
*
Author to whom correspondence should be addressed.
Academic Editor: Luigia Trabace
Received: 29 July 2016 / Revised: 7 September 2016 / Accepted: 14 September 2016 / Published: 30 September 2016
View Full-Text   |   Download PDF [737 KB, uploaded 30 September 2016]   |  

Abstract

Neurodegenerative diseases (ND) result from the gradual and progressive degeneration of the structure and function of the central nervous system or the peripheral nervous system or both. They are characterized by deterioration of neurons and/or myelin sheath, disruption of sensory information transmission and loss of movement control. There is no effective treatment for ND, and the drugs currently marketed are symptom-oriented, albeit with several side effects. Within the past decades, several natural remedies have gained attention as potential neuroprotective drugs. Moreover, an increasing number of studies have suggested that dietary intake of vegetables and fruits can prevent or delay the onset of ND. These properties are mainly due to the presence of polyphenols, an important group of phytochemicals that are abundantly present in fruits, vegetables, cereals and beverages. The main class of polyphenols is flavonoids, abundant in Citrus fruits. Our review is an overview on the scientific literature concerning the neuroprotective effects of the Citrus flavonoids in the prevention or treatment of ND. This review may be used as scientific basis for the development of nutraceuticals, food supplements or complementary and alternative drugs to maintain and improve the neurophysiological status. View Full-Text
Keywords: Citrus; flavonoids; neurodegeneration; neurodegenerative disorders; nutraceutical Citrus; flavonoids; neurodegeneration; neurodegenerative disorders; nutraceutical
Figures

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Cirmi, S.; Ferlazzo, N.; Lombardo, G.E.; Ventura-Spagnolo, E.; Gangemi, S.; Calapai, G.; Navarra, M. Neurodegenerative Diseases: Might Citrus Flavonoids Play a Protective Role? Molecules 2016, 21, 1312.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top