Novel Diterpenoids from the Twigs of Podocarpus nagi
AbstractPhytochemical investigation of the twigs of Podocarpus nagi (Podocarpaceae) led to the isolation of two new abietane-type diterpenoids, named 1β,16-dihydroxylambertic acid (1) and 3β,16-dihydroxylambertic acid (2), along with two new ent-pimarane-type diterpenoids, named ent-2β,15,16,18-tetrahydroxypimar-8(14)-ene (3) and ent-15-oxo-2β,16,18-trihydroxypimar-8(14)-ene (4). Their respective structures were elucidated on the basis of spectroscopic analyses, including 1D- and 2D-NMR, IR, CD, and HR-ESI-MS. This is the first time ent-pimarane-type diterpenoids from the genus Podocarpus has been reported. All four new compounds were tested for cytotoxic activity. The MTT assay results showed that compounds 3 and 4 significantly inhibited the proliferation of human cervical cancer Hela cells, human lung cancer A549 cells, and human breast cancer MCF-7 cells at a concentration of 10 μM. Furthermore, using the lipopolysaccharide (LPS)-stimulated RAW264.7 cells, compounds 2 and 4 were found to significantly inhibit nitrogen oxide (NO) production with IC50 values of 26.5 ± 6.1 and 17.1 ± 1.5 μM, respectively. View Full-Text
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Zheng, Y.-D.; Guan, X.-C.; Li, D.; Wang, A.-Q.; Ke, C.-Q.; Tang, C.- .; Lin, L.-G.; Ye, Y.; Wang, Z.-L.; Yao, S. Novel Diterpenoids from the Twigs of Podocarpus nagi. Molecules 2016, 21, 1282.
Zheng Y-D, Guan X-C, Li D, Wang A-Q, Ke C-Q, Tang C- , Lin L-G, Ye Y, Wang Z-L, Yao S. Novel Diterpenoids from the Twigs of Podocarpus nagi. Molecules. 2016; 21(10):1282.Chicago/Turabian Style
Zheng, Yuan-Dong; Guan, Xing-Chen; Li, Dan; Wang, An-Qi; Ke, Chang-Qiang; Tang, Chun- Ping; Lin, Li-Gen; Ye, Yang; Wang, Zheng-Liang; Yao, Sheng. 2016. "Novel Diterpenoids from the Twigs of Podocarpus nagi." Molecules 21, no. 10: 1282.
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