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Molecules 2015, 20(9), 17325-17338; doi:10.3390/molecules200917325

New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation

1
Department of Pharmaceutical Chemistry, "Iuliu Hațieganu" University of Medicine and Pharmacy 41 Victor Babeș Street, RO-400012 Cluj-Napoca, Romania
2
State Veterinary Laboratory for Animal Health and Safety, 1 Piața Mărăști Street, 400609 Cluj-Napoca, Romania
3
Department of Pharmacognosy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 12 Ion Creangă Street, RO-400010 Cluj-Napoca, Romania
*
Author to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 26 July 2015 / Revised: 3 September 2015 / Accepted: 9 September 2015 / Published: 18 September 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [836 KB, uploaded 18 September 2015]   |  

Abstract

New series of hydrazones 5–18 were synthesized, in good yields, by reacting 4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-carbohydrazide with differently substituted benzaldehyde. The resulting compounds were characterized via elemental analysis, physico-chemical and spectral data. An antimicrobial screening was done, using Gram (+), Gram (−) bacteria and one fungal strain. Tested molecules displayed moderate-to-good growth inhibition activity. 2,2-Diphenyl-1-picrylhydrazide assay was used to test the antioxidant properties of the compounds. Monohydroxy (14–16), para-fluorine (13) and 2,4-dichlorine (17) derivatives exhibited better free-radical scavenging ability than the other investigated molecules. View Full-Text
Keywords: thiazole; hydrazide; acyl-hydrazone; antibacterial; antifungal; antioxidant thiazole; hydrazide; acyl-hydrazone; antibacterial; antifungal; antioxidant
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Nastasă, C.; Tiperciuc, B.; Duma, M.; Benedec, D.; Oniga, O. New Hydrazones Bearing Thiazole Scaffold: Synthesis, Characterization, Antimicrobial, and Antioxidant Investigation. Molecules 2015, 20, 17325-17338.

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