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Molecules 2015, 20(9), 16987-17015; doi:10.3390/molecules200916987

Designing Dendrimer and Miktoarm Polymer Based Multi-Tasking Nanocarriers for Efficient Medical Therapy

Department of Chemistry, McGill University, 801 Sherbrooke St. West, Montreal, QC H3A 0B8, Canada
Author to whom correspondence should be addressed.
Academic Editor: Didier Astruc
Received: 11 August 2015 / Revised: 9 September 2015 / Accepted: 11 September 2015 / Published: 17 September 2015
(This article belongs to the Collection Nanomedicine)
View Full-Text   |   Download PDF [2031 KB, uploaded 17 September 2015]   |  


To address current complex health problems, there has been an increasing demand for smart nanocarriers that could perform multiple complimentary biological tasks with high efficacy. This has provoked the design of tailor made nanocarriers, and the scientific community has made tremendous effort in meeting daunting challenges associated with synthetically articulating multiple functions into a single scaffold. Branched and hyper-branched macromolecular architectures have offered opportunities in enabling carriers with capabilities including location, delivery, imaging etc. Development of simple and versatile synthetic methodologies for these nanomaterials has been the key in diversifying macromolecule based medical therapy and treatment. This review highlights the advancement from conventional “only one function” to multifunctional nanomedicine. It is achieved by synthetic elaboration of multivalent platforms in miktoarm polymers and dendrimers by physical encapsulation, covalent linking and combinations thereof. View Full-Text
Keywords: multifunctional; nanocarriers; dendrimers; miktoarm polymers; nanomedicine; drug delivery multifunctional; nanocarriers; dendrimers; miktoarm polymers; nanomedicine; drug delivery

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Sharma, A.; Kakkar, A. Designing Dendrimer and Miktoarm Polymer Based Multi-Tasking Nanocarriers for Efficient Medical Therapy. Molecules 2015, 20, 16987-17015.

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