Next Article in Journal
Investigating the Dissolution Performance of Amorphous Solid Dispersions Using Magnetic Resonance Imaging and Proton NMR
Next Article in Special Issue
Identification of Cultured and Natural Astragalus Root Based on Monosaccharide Mapping
Previous Article in Journal
Separation and Identification of Four New Compounds with Antibacterial Activity from Portulaca oleracea L.
Previous Article in Special Issue
Chemical Composition, Antioxidative and Anticancer Activities of the Essential Oil: Curcumae RhizomaSparganii Rhizoma, a Traditional Herb Pair
Article Menu

Export Article

Open AccessArticle
Molecules 2015, 20(9), 16388-16403; doi:10.3390/molecules200916388

Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells

1
State Key Laboratory of Phytochemistry and Plant Resources in West China, Institute of Chinese Medicine, the Chinese University of Hong Kong, Hong Kong, China
2
Department of Chemical Pathology, Prince of Wales Hospital, the Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
3
Department of Paediatrics, Prince of Wales Hospital, the Chinese University of Hong Kong, Shatin, NT, Hong Kong, China
4
Institute of Textiles and Clothing, the Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 August 2015 / Revised: 1 September 2015 / Accepted: 1 September 2015 / Published: 10 September 2015
(This article belongs to the Collection Herbal Medicine Research)
View Full-Text   |   Download PDF [1007 KB, uploaded 10 September 2015]   |  

Abstract

Atopic dermatitis (AD) is a widely prevalent and chronically relapsing inflammatory skin disease. Penta Herbs Formula (PHF) is efficacious in improving the quality of life and reducing topical corticosteroid used in children with AD and one of the active herbs it contains is Cortex Moutan. Recent studies showed that altered functions of dendritic cells (DC) were observed in atopic individuals, suggesting that DC might play a major role in the generation and maintenance of inflammation by their production of pro-inflammatory cytokines. Hence, the aims of the present study were to identify the major active component(s) of Cortex Moutan, which might inhibit DC functions and to investigate their possible interactions with conventional corticosteroid on inhibiting the development of DC from monocytes. Monocyte-derived dendritic cells (moDC) culture model coupled with the high-speed counter-current chromatography (HSCCC), high pressure liquid chromatography (HPLC) and Liquid Chromatography-Mass Spectrometry (LCMS) analyses were used. Gallic acid was the major active component from Cortex Moutan which could dose dependently inhibit interleukin (IL)-12 p40 and the functional cluster of differentiation (CD) surface markers CD40, CD80, CD83 and CD86 expression from cytokine cocktail-activated moDC. Gallic acid could also lower the concentration of hydrocortisone required to inhibit the activation of DC. View Full-Text
Keywords: atopic dermatitis; Cortex Moutan; dendritic cells; gallic acid; high-speed counter-current chromatography; Penta Herb Formula atopic dermatitis; Cortex Moutan; dendritic cells; gallic acid; high-speed counter-current chromatography; Penta Herb Formula
Figures

Figure 1

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

Scifeed alert for new publications

Never miss any articles matching your research from any publisher
  • Get alerts for new papers matching your research
  • Find out the new papers from selected authors
  • Updated daily for 49'000+ journals and 6000+ publishers
  • Define your Scifeed now

SciFeed Share & Cite This Article

MDPI and ACS Style

Chan, B.C.L.; Li, L.F.; Hu, S.Q.; Wat, E.; Wong, E.C.W.; Zhang, V.X.; Lau, C.B.S.; Wong, C.K.; Hon, K.L.E.; Hui, P.C.L.; Leung, P.C. Gallic Acid Is the Major Active Component of Cortex Moutan in Inhibiting Immune Maturation of Human Monocyte-Derived Dendritic Cells. Molecules 2015, 20, 16388-16403.

Show more citation formats Show less citations formats

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]

Molecules EISSN 1420-3049 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top