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Molecules 2015, 20(9), 15781-15796; doi:10.3390/molecules200915781

Chemical Composition, Antioxidative and Anticancer Activities of the Essential Oil: Curcumae RhizomaSparganii Rhizoma, a Traditional Herb Pair

1
School of Chinese Pharmacy, Beijing University of Chinese Medicine, Beijing 100102, China
2
Pharmacy College, Ningxia Medical University, Ningxia 750021, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 3 August 2015 / Revised: 20 August 2015 / Accepted: 25 August 2015 / Published: 28 August 2015
(This article belongs to the Collection Herbal Medicine Research)
View Full-Text   |   Download PDF [989 KB, uploaded 28 August 2015]   |  

Abstract

As a classical herb pair in clinics of traditional Chinese medicine, Curcumae RhizomaSparganii Rhizoma (HP CR–SR) is used for activating blood circulation to remove blood stasis. The essential components in HP CR–SR and its single herbs were comparatively analyzed using gas chromatography-mass spectrometry data. 66, 22, and 54 components in volatile oils of Curcumae Rhizoma, Sparganii Rhizoma, and HP CR–SR were identified, and total contents accounted for 75.416%, 91.857%, and 79.553% respectively. The thirty-eight components were found in HP CR–SR, and not detected in single herbs Curcumae Rhizoma and Sparganii Rhizoma. The highest radical trapping action was seen by an essential oil of HP CR–SR (IC50 = 0.59 ± 0.04 mg/mL). Furthermore, the HP CR–SR essential oil showed more remarkable cytotoxicity on tumor cell lines than that of the single herbs Curcumae Rhizoma and Sparganii Rhizoma in a dose-dependent manner: IC50 values showing 32.32 ± 5.31 μg/mL (HeLa), 34.76 ± 1.82 μg/mL (BGC823), 74.84 ± 1.66 μg/mL (MCF-7), 66.12 ± 11.23 μg/mL (SKOV3), and 708.24 ± 943.91 μg/mL (A549), respectively. In summary, the essential oil of HP CR–SR is different from any one of Curcumae Rhizoma and Sparganii Rhizoma, nor simply their superposition, and HP CR–SR oil presented more remarkable anticancer and antioxidant activities compared with Curcumae Rhizoma and Sparganii Rhizoma oils. View Full-Text
Keywords: Curcumae Rhizoma; Sparganii Rhizoma; Curcumae RhizomaSparganii Rhizoma; herb pair; essential oils; antioxidant activity; anti-cancer activity Curcumae Rhizoma; Sparganii Rhizoma; Curcumae RhizomaSparganii Rhizoma; herb pair; essential oils; antioxidant activity; anti-cancer activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Xu, G.-L.; Geng, D.; Xie, M.; Teng, K.-Y.; Tian, Y.-X.; Liu, Z.-Z.; Yan, C.; Wang, Y.; Zhang, X.; Song, Y.; Yang, Y.; She, G.-M. Chemical Composition, Antioxidative and Anticancer Activities of the Essential Oil: Curcumae RhizomaSparganii Rhizoma, a Traditional Herb Pair. Molecules 2015, 20, 15781-15796.

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