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Molecules 2015, 20(9), 15989-16003; doi:10.3390/molecules200915989

Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation

1
Center for Neuro-Medicine, Korea Institute of Science and Technology, Seoul 136-791, Korea
2
Department of Biotechnology, Yonsei University, Seoul 120-749, Korea
3
Department of Biological Chemistry, University of Science and Technology, Daejeon 305-350, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Peter Koulen
Received: 16 July 2015 / Revised: 18 August 2015 / Accepted: 28 August 2015 / Published: 2 September 2015
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Abstract

Imbalance in the antioxidant defense system leads to detrimental consequences, such as neurological disorders. The Nrf2 signaling is known as a main pathway involved in cellular defense system. Nrf2 is a transcription factor that regulates oxidative stress response by inducing expression of various antioxidant enzyme genes. In this study, we screened several pure natural compounds for Nrf2 activator. Among them, shizukahenriol (SZH), isolated from Chloranthus henryi, activated Nrf2, and induced expression of the Nrf2-dependent antioxidant enzymes HO-1, GCLC, and GCLM in BV-2 microglial cells. This natural compound was also effective in suppressing production of inflammatory molecules NO, TNF-α, and inhibition of NF-κB p65 translocation to the nucleus in a dose-dependent manner. We also examined whether SZH rescued the microglial cells from oxidative stress-induced cell death. Pretreatment with SZH dose-dependently attenuated H2O2-induced cytotoxicity in BV-2 microglial cells. These results suggested SZH as a potential neuroprotective agent for neurological disorders. View Full-Text
Keywords: nuclear factor-E2-related factor 2; neuroprotection; BV-2 mouse microglial cells; natural products; shizukahenriol nuclear factor-E2-related factor 2; neuroprotection; BV-2 mouse microglial cells; natural products; shizukahenriol
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Park, J.-H.; Choi, J.W.; Ju, E.J.; Pae, A.N.; Park, K.D. Antioxidant and Anti-Inflammatory Activities of a Natural Compound, Shizukahenriol, through Nrf2 Activation. Molecules 2015, 20, 15989-16003.

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