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Molecules 2015, 20(9), 15976-15988; doi:10.3390/molecules200915976

Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors

1
Department of Chemistry, Faculty of Science, Alexandria University, P. O. Box 426, Ibrahimia, Alexandria 21321, Egypt
2
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria 21521, Egypt
3
Department of Chemistry, College of Science, King Saud University, P. O. Box 2455, Riyadh 11451, Saudi Arabia
4
Catalysis and Peptide Research Unit, School of Health Sciences, University of KwaZulu-Natal, Durban 4001, South Africa
5
School of Chemistry and Physics, University of KwaZulu-Natal, Durban 4001, South Africa
6
Institute for Research in Biomedicine and CIBER-BBN, Barcelona 08028, Spain
7
Department of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain
*
Authors to whom correspondence should be addressed.
Academic Editor: Jean Jacques Vanden Eynde
Received: 22 May 2015 / Revised: 14 August 2015 / Accepted: 24 August 2015 / Published: 2 September 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [787 KB, uploaded 2 September 2015]   |  

Abstract

Three series of 4,6-dimethoxy-, 4,6-dipiperidino- and 4,6-dimorpholino-1,3,5-triazin-2-yl) amino acid derivatives were synthesized and characterized. A preliminary study for their monoamine oxidase inhibitory activity showed that compounds 7, 18, and 25 had MAO-A inhibition activity comparable to that of the standard clorgyline, with apparently more selective inhibitory activity toward MAO-A than MAO-B and no significant acute toxicity. View Full-Text
Keywords: 1,3,5-triazine derivatives; amino acids; morpholine; piperidine; monoamine oxidase 1,3,5-triazine derivatives; amino acids; morpholine; piperidine; monoamine oxidase
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Khattab, S.N.; Khalil, H.H.; Bekhit, A.A.; El-Rahman, M.M.A.; El-Faham, A.; Albericio, F. Synthesis and Preliminary Biological Evaluation of 1,3,5-Triazine Amino Acid Derivatives to Study Their MAO Inhibitors. Molecules 2015, 20, 15976-15988.

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