Concise Synthesis of Broussonone A
AbstractA concise and expeditious approach to the total synthesis of broussonone A, a p-quinol natural compound, has been developed. The key features of the synthesis include the Grubbs II catalyst mediated cross metathesis of two aromatic subunits, and a chemoselective oxidative dearomatizationin the presence of two phenol moieties. Especially, optimization associated with the CM reaction of ortho-alkoxystyrenes was also studied, which are known to be ineffective for Ru-catalyzed metathesis reactions under conventional reaction conditions because ortho-alkoxy group could coordinate to the ruthenium center, resulting in the potential complication of catalyst inhibition. View Full-Text
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Jo, H.; Choi, M.; Viji, M.; Lee, Y.H.; Kwak, Y.-S.; Lee, K.; Choi, N.S.; Lee, Y.-J.; Lee, H.; Hong, J.T.; Lee, M.K.; Jung, J.-K. Concise Synthesis of Broussonone A. Molecules 2015, 20, 15966-15975.
Jo H, Choi M, Viji M, Lee YH, Kwak Y-S, Lee K, Choi NS, Lee Y-J, Lee H, Hong JT, Lee MK, Jung J-K. Concise Synthesis of Broussonone A. Molecules. 2015; 20(9):15966-15975.Chicago/Turabian Style
Jo, Hyeju; Choi, Minho; Viji, Mayavan; Lee, Young H.; Kwak, Young-Shin; Lee, Kiho; Choi, Nam S.; Lee, Yeon-Ju; Lee, Heesoon; Hong, Jin T.; Lee, Mi K.; Jung, Jae-Kyung. 2015. "Concise Synthesis of Broussonone A." Molecules 20, no. 9: 15966-15975.