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Molecules 2015, 20(9), 15748-15765; doi:10.3390/molecules200915748

Antigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrin

Department of Plant Breeding, Institute of Sustainable Agriculture, CSIC, Avd. Menendez Pidal s/n, Córdoba E-14004, Spain
Department of Developmental and Molecular Biology, Chanin Building, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
Department of Genetics, Gregor Mendel Building, University of Córdoba, Rabanales, Córdoba 14014, Spain
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 26 June 2015 / Revised: 12 August 2015 / Accepted: 25 August 2015 / Published: 28 August 2015
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Cruciferous vegetables are well known and worldwide consumed due to their health benefits and cancer prevention properties. As a desirable cruciferous plant, Ethiopian mustard (Brassica carinata A. Braun) and its glucosinolate sinigrin were tested in the in vivo Drosophila melanogaster (SMART) and the in vitro HL60 (human promyelocytic leukaemia cell line) systems. High performance liquid chromatography (HPLC) analysis of plant samples confirmed the presence of sinigrin as principal B. carinata glucosinolate. SMART was performed by feeding D. melanogaster larvae either with different concentrations of plant/compound samples or combining them with hydrogen peroxide (a potent oxidative mutagen) being both antimutagenics. HL60 assays showed the tumoricidal activity of plant samples (IC50 = 0.28 mg·mL−1) and the breakdown products of sinigrin hydrolysis (IC50 = 2.71 µM). Our results enhance the potential of B. carinata as health promoter and chemopreventive in both systems and the leading role of sinigrin in these effects. View Full-Text
Keywords: Drosophila melanogaster; HL60; antigenotoxicity; cytotoxicity; Brassica; sinigrin; bioactive compound Drosophila melanogaster; HL60; antigenotoxicity; cytotoxicity; Brassica; sinigrin; bioactive compound

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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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Lozano-Baena, M.-D.; Tasset, I.; Obregón-Cano, S.; de Haro-Bailon, A.; Muñoz-Serrano, A.; Alonso-Moraga, Á. Antigenotoxicity and Tumor Growing Inhibition by Leafy Brassica carinata and Sinigrin. Molecules 2015, 20, 15748-15765.

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