Special Issue "Dietary Bioactive Compounds: Metabolism, Mechanisms and Translational Significance for Health and Prevention of Diseases"
Deadline for manuscript submissions: closed (30 June 2015)
A large range of molecules (often non-nutrients) found in the diet hold bioactive properties. A non-exhaustive list include the large (poly)phenolic family of compounds, glucosinolates, phytoestrogens, plant sterols, long chain fatty acids, selected vitamins and minerals, cereal fibre, and carotenoids.
Selected foods, predominantly of plant origin, have gained an important place in the consumer’s diet with a view to sustain health. The focus on dietary bioactive compounds is directly aligned with the emergence of functional foods in the last two decades, in parallel with the need to substantiate health claims.
Experimental design and appropriate methodologies are especially important to ascertain the metabolism, biological function, and mechanism of action of dietary bioactive compounds. An important addition is the need to discuss the translational value of these findings, and how they can influence commercial potential, public health, and clinical decision-making.
Contributions to this issue, both in the form of original research or review articles, may cover all aspects of dietary bioactive compound research, linking metabolism, biological function, and health or disease prevention. Studies with multidisciplinary input, offering new methodologies or insights are particularly welcome.
Dr. Emilie Combet
Dr. Maria Rosário Bronze
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Molecules is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1800 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- functional foods
- bioactive compounds
- disease prevention
- mechanism of action
- health claims
The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.
Title: New Carbamate Ester Prodrugs of Resveratrol. Synthesis, Characterization and in vivo Behavior
Authors: Andrea Mattarei 1,2, Michele Azzolini 3, Martina La Spina 2,3, Mario Zoratti 2,3, Lucia Biasutto2,3, Cristina Paradisi 1
Affiliation: 1 Department of Chemical Sciences, Via F. Marzolo 1, 35131 Padova, Italy
2 CNR Neuroscience Institute, Viale G. Colombo 3, 35121 Padova, Italy
3 Dept. Biomedical Sciences, University of Padova, Viale G. Colombo 3, 35121 Padova, Italy
Abstract: Resveratrol (3, 5, 4’-trihydroxy-trans-stilbene) exerts important biological activities, but its pharmacological exploitation in vivo is hindered by its rapid elimination via phase-II conjugative metabolism in the intestine and in the liver. One approach to bypass this problem relies on prodrugs. We report here the synthesis, characterization, stability and in vivo pharmacokinetics of 7 prodrugs of resveratrol, in which the OH groups are engaged in an N-monosubstituted carbamate ester and the isoleucine-comprising prodrugs were measurably absorbed, reaching the circulation as non-metabolized and partially hydrolyzed species.
The results suggest that prodrugs of resveratrol based on the N-monosubstituted carbamate ester bond may be a tool for the systemic delivery of the unconjugated parent compound; the promoiety linked to the nitrogen atom appears to be a key factor in modulating the properties of the prodrug.