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Molecules 2015, 20(8), 15273-15286; doi:10.3390/molecules200815273

Ultrasound-Assisted Aqueous Two-Phase System for Extraction and Enrichment of Zanthoxylum armatum Lignans

1
School of Life Science and Engineering, Lanzhou University of Technology, Lanzhou 730050, China
2
Hainan Provincial Key Laboratory of R & D of Tropical Plants, Hainan Medical University, Haikou 571101, China
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 16 June 2015 / Revised: 2 August 2015 / Accepted: 17 August 2015 / Published: 20 August 2015
(This article belongs to the Special Issue New Technologies for the Recovery of Natural Products)
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Abstract

In the study, an aqueous two phase system (ATPS) coupled with ultrasound was employed to extract lignans from Zanthoxylum armatum. Three standard lignans, namely (−)-fargesin, sesamin and L-asarinin, were used as marker compounds, and extraction was optimized and projected by response surface methodology (RSM) and artificial neural network (ANN). The optimal condition for ATPS with 20% n-propanol and 24% (NH4)2SO4 coupled with ultrasonic-assisted extraction including a solvent to solid ratio of 15:1, a temperature of 40 °C, and a treatment time of 55 min was obtained. Under the condition, the yield of (−)-fargesin increased 15.12%, and the purities of (−)-fargesin, sesamin and L-asarinin reached 2.222%, 1.066%, and 1.583%, with an increase of 44.38%, 25.70%, and 26.34% compared to those extracted with 95% ethanol, respectively. Coefficient of the determined (0.9855) and mean squared error (0.0018) of ANN model suggested good fitness and generalization of the ANN. Taken together, the results showed that ultrasonic-assisted ATPS can be a suitable method for extraction and enrichment of lignans from Z. armatum. View Full-Text
Keywords: Zanthoxylum armatum; lignans; aqueous two-phase system; ultrasonic-assisted extraction; artificial neural network; response surface methodology Zanthoxylum armatum; lignans; aqueous two-phase system; ultrasonic-assisted extraction; artificial neural network; response surface methodology
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Guo, T.; Su, D.; Huang, Y.; Wang, Y.; Li, Y.-H. Ultrasound-Assisted Aqueous Two-Phase System for Extraction and Enrichment of Zanthoxylum armatum Lignans. Molecules 2015, 20, 15273-15286.

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