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Molecules 2015, 20(6), 11076-11089; doi:10.3390/molecules200611076

Negative-Pressure Cavitation Extraction of Secoisolariciresinol Diglycoside from Flaxseed Cakes

1
College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China
2
Institute of Medicinal Plants, Yunnan Academy of Agricultural Sciences, Kunming 650205, China
*
Authors to whom correspondence should be addressed.
Academic Editor: Nigel Brunton
Received: 18 May 2015 / Accepted: 10 June 2015 / Published: 15 June 2015
(This article belongs to the Special Issue New Technologies for the Recovery of Natural Products)
View Full-Text   |   Download PDF [2743 KB, uploaded 17 June 2015]   |  

Abstract

The negative-pressure cavitation extraction (NPCE) technique was applied firstly to extract secoisolariciresinol diglucoside (SDG) from flaxseed cakes. The significant extraction parameters were screened by fractional factorial design (FFD). The optimal parameters were determined using the central composite design (CCD) with the two variables, NaOH amount and the liquid/solid ratio. The conditions of the extraction were optimized by using response surface methodology (RSM). Under the optimal conditions, the extraction yield and the extraction purity of SDG was 16.25 mg/g and 3.86%, respectively. The efficiency of NPCE was compared with that of conventional extraction methods. Our results demonstrated that NPCE was comparable to the well-known ultrasound-assisted extraction in term of extraction yield and purity. This extraction technique has advantages of less time-consuming, low solvent usage and high throughput capability. View Full-Text
Keywords: flaxseed cake; negative-pressure cavitation extraction; pilot-scale application; response surface methodology; secoisolariciresinol diglucoside flaxseed cake; negative-pressure cavitation extraction; pilot-scale application; response surface methodology; secoisolariciresinol diglucoside
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Tian, H.; Li, W.-Y.; Xiao, D.; Li, Z.-M.; Wang, J.-W. Negative-Pressure Cavitation Extraction of Secoisolariciresinol Diglycoside from Flaxseed Cakes. Molecules 2015, 20, 11076-11089.

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