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Molecules 2015, 20(8), 14082-14102; doi:10.3390/molecules200814082

Mosquitocidal and Oviposition Repellent Activities of the Extracts of Seaweed Bryopsis pennata on Aedes aegypti and Aedes albopictus

1
Drug and Herbal Research Centre, Faculty of Pharmacy, Universiti Kebangsaan Malaysia, 50300 Kuala Lumpur, Malaysia
2
School of Biosciences, Taylor's University, Taylor's Lakeside Campus, Subang Jaya, 47500 Selangor, Malaysia
3
Medical Entomology Unit, Infectious Disease Research Centre, Institute for Medical Research, 50588 Kuala Lumpur, Malaysia
*
Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 16 June 2015 / Revised: 28 July 2015 / Accepted: 29 July 2015 / Published: 4 August 2015
(This article belongs to the Section Natural Products)
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Abstract

The ever-increasing threat from infectious diseases and the development of insecticide resistance in mosquito populations drive the global search for new natural insecticides. The aims of this study were to evaluate the mosquitocidal activity of the extracts of seaweed Bryopsis pennata against dengue vectors Aedes aegypti and Aedes albopictus, and determine the seaweed’s toxic effect on brine shrimp nauplii (as a non-target organism). In addition, the chemical compositions of the active larvicidal extract and fraction were analyzed by using liquid chromatography-mass spectrometry (LC-MS). Chloroform extract exhibited strong ovicidal activity (with LC50 values of 229.3 and 250.5 µg/mL) and larvicidal activity against Ae. aegypti and Ae. albopictus. The larvicidal potential of chloroform extract was further ascertained when its A7 fraction exhibited strong toxic effect against Ae. aegypti (LC50 = 4.7 µg/mL) and Ae. albopictus (LC50 = 5.3 µg/mL). LC-MS analysis of the chloroform extract gave a tentative identification of 13 compounds; Bis-(3-oxoundecyl) tetrasulfide was identified as the major compound in A7 fraction. Methanol extract showed strong repellent effect against female oviposition, along with weak adulticidal activity against mosquito and weak toxicity against brine shrimp nauplii. The mosquitocidal results of B. pennata suggest further investigation for the development of effective insecticide. View Full-Text
Keywords: dengue vector; ovicidal; larvicidal; insecticide; bis-(3-oxoundecyl) tetrasulfide dengue vector; ovicidal; larvicidal; insecticide; bis-(3-oxoundecyl) tetrasulfide
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Yu, K.-X.; Wong, C.-L.; Ahmad, R.; Jantan, I. Mosquitocidal and Oviposition Repellent Activities of the Extracts of Seaweed Bryopsis pennata on Aedes aegypti and Aedes albopictus. Molecules 2015, 20, 14082-14102.

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