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Molecules 2015, 20(8), 14051-14081; doi:10.3390/molecules200814051

Nanostructures for the Inhibition of Viral Infections

Institute of Electronics, Microelectronics and Nanotechnology (IEMN), UMR 8520 CNRS, Lille1 University, Avenue Poincaré—BP 60069, 59652 Villeneuve d\'Ascq, France
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Author to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 5 July 2015 / Revised: 21 July 2015 / Accepted: 28 July 2015 / Published: 3 August 2015
(This article belongs to the Section Medicinal Chemistry)
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Abstract

Multivalent interactions are omnipresent in biology and confer biological systems with dramatically enhanced affinities towards different receptors. Such multivalent binding interactions have lately been considered for the development of new therapeutic strategies against bacterial and viral infections. Multivalent polymers, dendrimers, and liposomes have successfully targeted pathogenic interactions. While a high synthetic effort was often needed for the development of such therapeutics, the integration of multiple ligands onto nanostructures turned to be a viable alternative. Particles modified with multiple ligands have the additional advantage of creating a high local concentration of binding molecules. This review article will summarize the different nanoparticle-based approaches currently available for the treatment of viral infections. View Full-Text
Keywords: viral infections; antiviral therapy; nanomaterials viral infections; antiviral therapy; nanomaterials
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Szunerits, S.; Barras, A.; Khanal, M.; Pagneux, Q.; Boukherroub, R. Nanostructures for the Inhibition of Viral Infections. Molecules 2015, 20, 14051-14081.

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