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Open AccessCommunication
Molecules 2015, 20(7), 12198-12208; doi:10.3390/molecules200712198

Enzyme Inhibitory Radicinol Derivative from Endophytic fungus Bipolaris sorokiniana LK12, Associated with Rhazya stricta

1
UoN Chair of Oman's Medicinal Plants and Marine Natural Products, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman
2
Department of Biological Sciences and Chemistry, College of Arts and Sciences, University of Nizwa, Birkat Al-Mouz, Nizwa 616, Oman
3
School of Applied Biosciences, Kyungpook National University, Daegu 702-701, Korea
*
Authors to whom correspondence should be addressed.
Academic Editor: Isabel C.F.R. Ferreira
Received: 3 May 2015 / Revised: 17 June 2015 / Accepted: 30 June 2015 / Published: 3 July 2015
(This article belongs to the Collection Bioactive Compounds)
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Abstract

Endophytes, living inside plant tissues, play an essential role in plant growth and development, whilst producing unique bioactive secondary metabolites. In the current study, the endophytic fungus Bipolaris sorokiniana LK12 was isolated from the leaves of ethno-medicinal and alkaloidal rich Rhazya stricta. The bulk amount of ethyl acetate extract of fungus was subjected to advance column chromatographic techniques, which resulted in the isolation of a new radicinol derivative, bipolarisenol (1). It was found to be a derivative of radicinol. The structure elucidation was carried out by the combined use of 1D and 2D nuclear magnetic resonance, infrared spectroscopy, mass, and UV spectrometric analyses. The bipolarisenol was assessed for its potential role in enzyme inhibition of urease and acetyl cholinesterase (AChE). Results showed that bipolarisenol significantly inhibited the AChE activity with low IC50 (67.23 ± 5.12 µg·mL−1). Bipolarisenol inhibited urease in a dose-dependent manner with high IC50 (81.62 ± 4.61 µg·mL−1). The new compound also showed a moderate anti-lipid peroxidation potential (IC50 = 168.91 ± 4.23 µg·mL−1). In conclusion, endophytes isolated from medicinal plants possess a unique potential to be considered for future drug discovery. View Full-Text
Keywords: radicinol; bipolarisenol; Rhazya stricta; Bipolaris sorokiniana LK12; lipid peroxidation; enzyme inhibition radicinol; bipolarisenol; Rhazya stricta; Bipolaris sorokiniana LK12; lipid peroxidation; enzyme inhibition
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Khan, A.L.; Ali, L.; Hussain, J.; Rizvi, T.S.; Al-Harrasi, A.; Lee, I.-J. Enzyme Inhibitory Radicinol Derivative from Endophytic fungus Bipolaris sorokiniana LK12, Associated with Rhazya stricta. Molecules 2015, 20, 12198-12208.

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