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Molecules 2015, 20(7), 12166-12174; doi:10.3390/molecules200712166

Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties

School of Pharmacy, College of Pharmacy, Kaohsiung Medical University, Kaohsiung 807, Taiwan
Department of Nursing, Tzu Hui Institute of Technology, Pingtung County 926, Taiwan
Department of Nutrition and Health Science, School of Medical and Health Sciences, Fooyin University, Kaohsiung 831, Taiwan
Authors to whom correspondence should be addressed.
Academic Editor: Derek J. McPhee
Received: 29 May 2015 / Revised: 26 June 2015 / Accepted: 1 July 2015 / Published: 3 July 2015
(This article belongs to the Section Medicinal Chemistry)
View Full-Text   |   Download PDF [701 KB, uploaded 3 July 2015]   |  


Seven compounds were extracted and purified from the roots of Michelia compressa var. lanyuensis. These compounds are liriodenine, (−)-N-acetylanonaine, pressalanine A, p-dihydroxybenzaldehyde, 3,4-dihydroxybenzoic acid, (−)-bornesitol and β-sitostenone. These compounds were screened for anti-proliferation and anti-tyrosinase activities in B16F10 cells. Liriodenine, pressalanine A, (−)-bornesitol and β-sitostenone displayed cytotoxicity at high concentration (100 μM), but liriodenine (5 μM), (−)-N-acetylanonaine (10 μM), and β-sitostenone (5 μM) inhibit tyrosinase activity and reduce the melanin content in B16F10 cells without cytotoxicity, suggesting that liriodenine and β-sitostenone could be safe and potentially used in cosmetic skin whitening. View Full-Text
Keywords: Michelia compressa var. lanyuensis; Magnoliaceae; tyrosinase activity; melanin Michelia compressa var. lanyuensis; Magnoliaceae; tyrosinase activity; melanin

Figure 1a

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Chu, C.-W.; Liu, C.-M.; Chung, M.-I.; Chen, C.-Y. Biofunctional Constituents from Michelia compressa var. lanyuensis with Anti-Melanogenic Properties. Molecules 2015, 20, 12166-12174.

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