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Molecules 2015, 20(7), 12154-12165; doi:10.3390/molecules200712154

Antioxidative and Anticanceric Activities of Magnolia (Magnolia denudata) Flower Petal Extract Fermented by Pediococcus acidilactici KCCM 11614

1
Department of Food Science and Biotechnology of Animal Resources, Konkuk University, Seoul 143-701, Korea
2
Bio/Molecular Informatics Center, Konkuk University, Seoul 143-701, Korea
*
Author to whom correspondence should be addressed.
Academic Editor: Maurizio Battino
Received: 14 May 2015 / Revised: 29 June 2015 / Accepted: 30 June 2015 / Published: 3 July 2015
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Abstract

In this study, the effects of magnolia (Magnolia (M.) denudata) extract fermentation in increasing the extract’s antioxidative and anticancer activities were investigated. Magnolia was fermented by Pediococcus acidilactici KCCM 11614. The total phenolic content was determined by the Folin-Ciocalteu’s method and the antioxidative effects by 1,1-diphenyl-2-picrylhydrazy (DPPH) and ferric reducing ability of plasma (FRAP) assay. Anticancer activity against cancer and normal cells was determined using 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyltetrazolium bromide (MTT). Total phenolic content during fermentation increased from 38.1 to 47.0 mg gallic acid equivalent (GAE)/g of solid matter. The radical scavenging activity was 91.4% after 72 h fermentation. Fermented magnolia’s antioxidative effect was threefold higher than that of the (non-fermented) control. Fermentation (48 h) increased anticanceric activity against AGS, LoVo, and MCF-7 cancer cells 1.29- to 1.36-fold compared with that of the control, but did not affect MRC-5 (normal) cells, suggesting that fermented magnolia could be used as a natural antioxidative and anticancer agent. View Full-Text
Keywords: flavonoid; Pediococcus acidilactici; Magnolia denudate; antioxidative effect; anticanceric activity flavonoid; Pediococcus acidilactici; Magnolia denudate; antioxidative effect; anticanceric activity
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. (CC BY 4.0).

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MDPI and ACS Style

Park, H.; Kim, H.-S.; Eom, S.J.; Kim, K.-T.; Paik, H.-D. Antioxidative and Anticanceric Activities of Magnolia (Magnolia denudata) Flower Petal Extract Fermented by Pediococcus acidilactici KCCM 11614. Molecules 2015, 20, 12154-12165.

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